6w2i: Difference between revisions
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==Crystal Structure of Y188G Variant of the Internal UBA Domain of HHR23A== | ==Crystal Structure of Y188G Variant of the Internal UBA Domain of HHR23A== | ||
<StructureSection load='6w2i' size='340' side='right'caption='[[6w2i]]' scene=''> | <StructureSection load='6w2i' size='340' side='right'caption='[[6w2i]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W2I FirstGlance]. <br> | <table><tr><td colspan='2'>[[6w2i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W2I FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w2i OCA], [https://pdbe.org/6w2i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w2i RCSB], [https://www.ebi.ac.uk/pdbsum/6w2i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w2i ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAD23A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w2i OCA], [https://pdbe.org/6w2i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w2i RCSB], [https://www.ebi.ac.uk/pdbsum/6w2i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w2i ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/RD23A_HUMAN RD23A_HUMAN]] Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.<ref>PMID:9372924</ref> <ref>PMID:14621999</ref> <ref>PMID:12643283</ref> <ref>PMID:15321727</ref> <ref>PMID:20614012</ref> Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.<ref>PMID:9372924</ref> <ref>PMID:14621999</ref> <ref>PMID:12643283</ref> <ref>PMID:15321727</ref> <ref>PMID:20614012</ref> Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.<ref>PMID:9372924</ref> <ref>PMID:14621999</ref> <ref>PMID:12643283</ref> <ref>PMID:15321727</ref> <ref>PMID:20614012</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Becht | [[Category: Becht, D C]] | ||
[[Category: Bowler | [[Category: Bowler, B E]] | ||
[[Category: Mou T | [[Category: Mou, T C]] | ||
[[Category: Rothfuss M]] | [[Category: Rothfuss, M]] | ||
[[Category: Sprang | [[Category: Sprang, S R]] | ||
[[Category: Zeng B]] | [[Category: Zeng, B]] | ||
[[Category: Dna binding protein]] | |||
[[Category: Helical bundle]] | |||
[[Category: Uba domain]] | |||
[[Category: Ubiquitin associated domain]] | |||