Nitric Oxide Synthase: Difference between revisions
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The NO production takes plase in the oxygenase domain, whereas the reductase domain provides the electrons necessary to drive the reaction in the oxygenase domain. | The NO production takes plase in the oxygenase domain, whereas the reductase domain provides the electrons necessary to drive the reaction in the oxygenase domain. | ||
The reaction is: | The reaction is: | ||
[[image:Makroprojekt-chemdraw-1-.gif|left|thumb| | [[image:Makroprojekt-chemdraw-1-.gif|frame|left|thumb|400px]] | ||
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The reaction occurs in two steps. In the first step L-arginine is turned in to N-hydroxy-arginine. In the second step L-citrulline and NO are formed. The reaction utilizes 2O<sub>2</sub> and 3 electrons from 3/2 NADPH.<ref>PMID:17014963</ref> | The reaction occurs in two steps. In the first step L-arginine is turned in to N-hydroxy-arginine. In the second step L-citrulline and NO are formed. The reaction utilizes 2O<sub>2</sub> and 3 electrons from 3/2 NADPH.<ref>PMID:17014963</ref> | ||