6z2h: Difference between revisions
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==Citryl-CoA lyase module of human ATP citrate lyase in complex with (3S)-citryl-CoA.== | ==Citryl-CoA lyase module of human ATP citrate lyase in complex with (3S)-citryl-CoA.== | ||
<StructureSection load='6z2h' size='340' side='right'caption='[[6z2h]]' scene=''> | <StructureSection load='6z2h' size='340' side='right'caption='[[6z2h]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z2H FirstGlance]. <br> | <table><tr><td colspan='2'>[[6z2h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z2H FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z2h OCA], [https://pdbe.org/6z2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z2h RCSB], [https://www.ebi.ac.uk/pdbsum/6z2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z2h ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene>, <scene name='pdbligand=Q5B:(3S)-citryl-Coenzyme+A'>Q5B</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6hxk|6hxk]], [[6hxl|6hxl]]</div></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACLY ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/ATP_citrate_synthase ATP citrate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.8 2.3.3.8] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z2h OCA], [https://pdbe.org/6z2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z2h RCSB], [https://www.ebi.ac.uk/pdbsum/6z2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z2h ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/ACLY_HUMAN ACLY_HUMAN]] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.<ref>PMID:23932781</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: ATP citrate synthase]] | |||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Verschueren | [[Category: Verschueren, K H.G]] | ||
[[Category: Verstraete K]] | [[Category: Verstraete, K]] | ||
[[Category: Acetyl-coa production]] | |||
[[Category: Atp citrate lyase]] | |||
[[Category: Lipogenesis]] | |||
[[Category: Lyase]] | |||
[[Category: Metabolism]] | |||