Growth factors: Difference between revisions
No edit summary |
No edit summary |
||
| Line 104: | Line 104: | ||
<scene name='80/805035/Cv/5'>Site 3</scene>. | <scene name='80/805035/Cv/5'>Site 3</scene>. | ||
[[High affinity nerve growth factor receptor]] | **[[High affinity nerve growth factor receptor]] | ||
'''TrkA'''. Trk stands for Topomyosin-Related Kinase. TrkA ligand - nerve growth factor activates the receptor by stabilizing homodimer formation which initiates transautophosphorylation. <scene name='80/805001/Cv/4'>Structure of Nerve Growth Factor Complexed with the Extracellular Domain of TrkA</scene>. An <scene name='80/805001/Cv/7'>Arg residue</scene>, conserved in all neutrophins, forms the most important binding determinant between TrkA and its ligand - nerve growth factor - which forms the active homodimer of the receptor. <scene name='80/805001/Cv/6'>All interactions between TrkA chain A and NGF</scene>. | '''TrkA'''. Trk stands for Topomyosin-Related Kinase. TrkA ligand - nerve growth factor activates the receptor by stabilizing homodimer formation which initiates transautophosphorylation. <scene name='80/805001/Cv/4'>Structure of Nerve Growth Factor Complexed with the Extracellular Domain of TrkA</scene>. An <scene name='80/805001/Cv/7'>Arg residue</scene>, conserved in all neutrophins, forms the most important binding determinant between TrkA and its ligand - nerve growth factor - which forms the active homodimer of the receptor. <scene name='80/805001/Cv/6'>All interactions between TrkA chain A and NGF</scene>. | ||
[[Tyrosine kinase receptor|Tyrosine kinase receptor TrkA]] | **[[Tyrosine kinase receptor|Tyrosine kinase receptor TrkA]] | ||
TRK-A contains an extracellular ligand binding domain (LBD), a transmembrane helix and an intracellular region which contains the kinase domain. The kinase domain ([[4yne]]) contains the tripeptide DFG which flips out in TRK-A inactivated form. <scene name='83/839914/Cv/7'>Inhibitor binding site</scene> ([[4yne]]). The structure of the complex of TRK-A with the phenylpyrrolidine derivative shows the inhibitor forming hydrogen bonds to Met620 and Lys572 residues and π-π interactions of it with Phe617 and Phe 698. | TRK-A contains an extracellular ligand binding domain (LBD), a transmembrane helix and an intracellular region which contains the kinase domain. The kinase domain ([[4yne]]) contains the tripeptide DFG which flips out in TRK-A inactivated form. <scene name='83/839914/Cv/7'>Inhibitor binding site</scene> ([[4yne]]). The structure of the complex of TRK-A with the phenylpyrrolidine derivative shows the inhibitor forming hydrogen bonds to Met620 and Lys572 residues and π-π interactions of it with Phe617 and Phe 698. | ||
| Line 114: | Line 114: | ||
The <scene name='83/839914/Cv/4'>complex between TRK-A and the nerve growth factor</scene> ([[2ifg]]) is a 2:2 dimer. The C-terminal immunoglobulin-like domain interacts with the NGF. The extracellular domain of TRK-A contains <scene name='83/839914/Cv/5'>3 Leu-rich regions</scene> flanked by <scene name='83/839914/Cv/6'>Cys-rich regions</scene> (in yellow), 2 immunoglobulin-like domains and the nerve growth factor (NGF) binding domain. | The <scene name='83/839914/Cv/4'>complex between TRK-A and the nerve growth factor</scene> ([[2ifg]]) is a 2:2 dimer. The C-terminal immunoglobulin-like domain interacts with the NGF. The extracellular domain of TRK-A contains <scene name='83/839914/Cv/5'>3 Leu-rich regions</scene> flanked by <scene name='83/839914/Cv/6'>Cys-rich regions</scene> (in yellow), 2 immunoglobulin-like domains and the nerve growth factor (NGF) binding domain. | ||
[[TrkB tyrosine kinase receptor]] | **[[TrkB tyrosine kinase receptor]] | ||
<scene name='80/805008/Cv/6'>Structure of the TrkB-d5:NT-4/5 Complex, comprising one homodimer of NT-4/5 bound to two monomers of TrkB-d5</scene>. TrkB and neutrotrophin-4/5 interact via a <scene name='80/805008/Cv/7'>specificity interaction site</scene> and via a <scene name='80/805008/Cv/8'>conserved interaction site</scene>. | <scene name='80/805008/Cv/6'>Structure of the TrkB-d5:NT-4/5 Complex, comprising one homodimer of NT-4/5 bound to two monomers of TrkB-d5</scene>. TrkB and neutrotrophin-4/5 interact via a <scene name='80/805008/Cv/7'>specificity interaction site</scene> and via a <scene name='80/805008/Cv/8'>conserved interaction site</scene>. | ||