Growth factors: Difference between revisions
No edit summary |
No edit summary |
||
| Line 20: | Line 20: | ||
*[[Ephrin]] and [[Ephrin receptor]] | *[[Ephrin]] and [[Ephrin receptor]] | ||
'''Ephrins''' (Eph) are the membrane-bound ligands of ephrin receptors. The binding of Eph and ephrin receptors is achieved via cell-cell interaction. Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation <ref>PMID:17420126</ref> | '''Ephrins''' (Eph) are the membrane-bound ligands of ephrin receptors. The binding of Eph and ephrin receptors is achieved via cell-cell interaction. Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation <ref>PMID:17420126</ref>. Eph-A5 is implicated in spinal cord injury. Eph-A1 is implicated in myocardial injury and renal reperfusion injury. <scene name='59/594659/Cv/4'>Ephrin-A5 receptor-binding domain complex with ephrin type A receptor 2</scene> (PDB code [[3mx0]]).<ref>PMID:20505120</ref> | ||
<scene name='45/450911/Cv/8'>Ephrin A3 receptor with peptide substrate, nucleotide derivative and Mg+2 ion</scene>. Water molecules are shown as red spheres. | |||
<scene name='45/450911/Cv/9'>Nucleotide derivative and Mg+2 ion binding site</scene>. | |||
<scene name='45/450911/Cv/10'>Peptide substrate binding site</scene> ([[3fxx]]).<ref>PMID:19678838</ref> | |||
*[[Erythropoietin]] and [[Erythropoietin receptor]] | *[[Erythropoietin]] and [[Erythropoietin receptor]] | ||
*[[Fibroblast growth factor]] and [[Fibroblast growth factor receptor]] | *[[Fibroblast growth factor]] and [[Fibroblast growth factor receptor]] | ||