1ft0: Difference between revisions

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<StructureSection load='1ft0' size='340' side='right'caption='[[1ft0]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='1ft0' size='340' side='right'caption='[[1ft0]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ft0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FT0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ft0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FT0 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fso|1fso]], [[1fst|1fst]], [[1ft3|1ft3]]</td></tr>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fso|1fso]], [[1fst|1fst]], [[1ft3|1ft3]]</div></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ft0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ft0 OCA], [http://pdbe.org/1ft0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ft0 RCSB], [http://www.ebi.ac.uk/pdbsum/1ft0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ft0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ft0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ft0 OCA], [https://pdbe.org/1ft0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ft0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ft0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ft0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GDIR1_HUMAN GDIR1_HUMAN]] Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity).  
[[https://www.uniprot.org/uniprot/GDIR1_HUMAN GDIR1_HUMAN]] Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity).  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

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