1dnn: Difference between revisions
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<StructureSection load='1dnn' size='340' side='right'caption='[[1dnn]]' scene=''> | <StructureSection load='1dnn' size='340' side='right'caption='[[1dnn]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DNN FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dnn FirstGlance], [https://www.ebi.ac.uk/pdbsum/1dnn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dnn ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
Latest revision as of 12:29, 21 July 2021
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SMOOTH BENDING OF DNA IN CHROMATINSMOOTH BENDING OF DNA IN CHROMATIN
Structural highlights
Publication Abstract from PubMedThe idea that DNA in chromatin can be packed smoothly, without breaking of base-stacking interactions, has been explored by both energetical estimations and stereochemical model building. A model of deformed DNA is built that fits reasonably to the known dimensions of a nucleosome. The model has slightly changed torsion angles in the sugarphosphate moieties relative to B DNA, varying gradually along the chains. The angle between planes of adjacent base pairs varies between 1 and 7 degrees. This model of deformed DNA does not have any unusually close nonbonded contacts and is evidently not the only possible model of smooth packing of DNA in chromatin. An energetical estimation of the critical radius of curvature of a smoothly bent DNA molecule is made using approximate potential functions for different van der Waals contracts in the B DNA structure. The critical radius of curvature of the deformed DNA-axis is close to the radius of a nucleosome (similar to 50 A). The smooth packing is a good alternative to models of kinked folding of DNA in nucleosomes. Possibility of nonkinked packing of DNA in chromatin.,Sussman JL, Trifonov EN Proc Natl Acad Sci U S A. 1978 Jan;75(1):103-7. PMID:272625[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References |
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