1evt: Difference between revisions

Revision as of 15:34, 2 May 2008

CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1)

OverviewOverview

To elucidate the structural determinants governing specificity in fibroblast growth factor (FGF) signaling, we have determined the crystal structures of FGF1 and FGF2 complexed with the ligand binding domains (immunoglobulin-like domains 2 [D2] and 3 [D3]) of FGF receptor 1 (FGFR1) and FGFR2, respectively. Highly conserved FGF-D2 and FGF-linker (between D2-D3) interfaces define a general binding site for all FGF-FGFR complexes. Specificity is achieved through interactions between the N-terminal and central regions of FGFs and two loop regions in D3 that are subject to alternative splicing. These structures provide a molecular basis for FGF1 as a universal FGFR ligand and for modulation of FGF-FGFR specificity through primary sequence variations and alternative splicing.

About this StructureAbout this Structure

1EVT is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity., Plotnikov AN, Hubbard SR, Schlessinger J, Mohammadi M, Cell. 2000 May 12;101(4):413-24. PMID:10830168 Page seeded by OCA on Fri May 2 15:34:44 2008

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OCA

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 [[Image:1evt.gif|left|200px]]
- {{Structure
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-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1evt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1evt OCA], [http://www.ebi.ac.uk/pdbsum/1evt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1evt RCSB]</span>
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 '''CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1)'''
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 [[Category: Plotnikov, A N.]]
 [[Category: Schlessinger, J.]]
-[[Category: b-trefoil fold]]
+[[Category: B-trefoil fold]]
-[[Category: immunoglobulin (ig) like domains belonging to the i-set subgroup within ig-like domain]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 15:34:44 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:10:37 2008''