Ephrin: Difference between revisions

Revision as of 13:30, 15 July 2021

Function

Ephrins (Eph) are the membrane-bound ligands of ephrin receptors. The binding of Eph and ephrin receptors is achieved via cell-cell interaction. Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation ^[1]. See also Ephrin receptor

Disease

Eph-A5 is implicated in spinal cord injury. Eph-A1 is implicated in myocardial injury and renal reperfusion injury.

Structural highlights

(PDB code 3mx0).^[2]

Structure of glycosylated human ephrin-A5 receptor-binding domain (green) complex with ephrin type A receptor 2 (cyan) (PDB code 3mx0).

Drag the structure with the mouse to rotate

3D structures of ephrin3D structures of ephrin

Updated on 15-July-2021

ReferencesReferences

↑ Egea J, Klein R. Bidirectional Eph-ephrin signaling during axon guidance. Trends Cell Biol. 2007 May;17(5):230-8. Epub 2007 Apr 8. PMID:17420126 doi:http://dx.doi.org/10.1016/j.tcb.2007.03.004
↑ Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S. Architecture of Eph receptor clusters. Proc Natl Acad Sci U S A. 2010 May 26. PMID:20505120

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Egea J, Klein R. Bidirectional Eph-ephrin signaling during axon guidance. Trends Cell Biol. 2007 May;17(5):230-8. Epub 2007 Apr 8. PMID:17420126 doi:http://dx.doi.org/10.1016/j.tcb.2007.03.004

[2] Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S. Architecture of Eph receptor clusters. Proc Natl Acad Sci U S A. 2010 May 26. PMID:20505120

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[2]

@@ Line 17: / Line 17: @@
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 {{#tree:id=OrganizedByTopic|openlevels=0|
+*Ephrin-A1
+**[[3hei]], [[3mbw]], [[3czu]] – hEph receptor-binding domain + Eph type A receptor 2 <br />
+**[[3fl7]] – hEph ectodomain  <br />
+*Ephrin-A2
+**[[2wo3]] – hEph receptor-binding domain + Eph type A receptor 4 <br />
+* Ephrin-A3
+**[[3dzq]] – hEph kinase domain + inhibitor <br />
 *Ephrin-A5
@@ Line 46: / Line 59: @@
 **[[4bkf]] – hEph receptor-binding domain + Eph type A receptor 4 <br />
 **[[3d12]] – mEph receptor-binding domain + virus hemagglutinin neuraminidase <br />
-*Ephrin-A1
-**[[3hei]], [[3mbw]], [[3czu]] – hEph receptor-binding domain + Eph type A receptor 2 <br />
-**[[3fl7]] – hEph ectodomain  <br />
-*Ephrin-A2
-**[[2wo3]] – hEph receptor-binding domain + Eph type A receptor 4 <br />
-* Ephrin-A3
-**[[3dzq]] – hEph kinase domain + inhibitor <br />
 }}