1c8p: Difference between revisions

<table><tr><td colspan='2'>[[1c8p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1d4q 1d4q]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C8P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C8P FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c8p OCA], [http://pdbe.org/1c8p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c8p RCSB], [http://www.ebi.ac.uk/pdbsum/1c8p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1c8p ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN]] Defects in CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5) [MIM:[http://omim.org/entry/614370 614370]]. SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:21075760</ref>   

[[http://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN]] High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.