Protein crosslinks: Difference between revisions
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====Thioester Bonds==== | ====Thioester Bonds==== | ||
[[Thioester protein crosslinks|Thioester bonds]]: Again, an estimate of frequency may not be available. A text search for "thioester" at RCSB.Org gives ~2,000 hits, while a text search at PDBe gives ~1,400 hits (July, 2021). Among a sample of 5 of the PDBe hits (every 100th in the listing), none had thioester bonds, but most contained terms such as "thioesterase" or "thioester". RCSB Advanced Search has "Biologically Interesting Molecules (BIRD): BIRD Type = Thioester", which gives 19 hits (July, 2021). However, only 2% of entries have BIRD annotations. | [[Thioester protein crosslinks|Thioester bonds]]: Again, an estimate of frequency may not be available. A text search for "thioester" at RCSB.Org gives ~2,000 hits, while a text search at PDBe gives ~1,400 hits (July, 2021). Among a sample of 5 of the PDBe hits (every 100th in the listing), none had thioester bonds, but most contained terms such as "thioesterase" or "thioester". Adding "and not thioesterase" reduced the hits to ~500. RCSB Advanced Search has "Biologically Interesting Molecules (BIRD): BIRD Type = Thioester", which gives 19 hits (July, 2021). However, only 2% of entries have BIRD annotations. | ||
**Example: Bacterial pilus adhesin [[2xi9]] has 2 thioester bonds (and 2 isopeptide bonds). | **Example: Bacterial pilus adhesin [[2xi9]] has 2 thioester bonds (and 2 isopeptide bonds). | ||