Protein crosslinks: Difference between revisions
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The subject of this article is covalent crosslinks between polypeptides, either between protein chains (int'''<u>er</u>'''chain crosslinks), or within chains (int'''<u>ra</u>'''chain crosslinks). | Proteins are linear (unbranched) polypeptide [[chains]] of [[amino acids]]. The subject of this article is covalent crosslinks between polypeptides, either between protein chains (int'''<u>er</u>'''chain crosslinks), or within chains (int'''<u>ra</u>'''chain crosslinks). | ||
==Natural Crosslinks== | ==Natural Crosslinks== | ||
*[[Disulfide bonds]] are the most common protein crosslinks. About 23% of protein structures in the [[PDB]] have disulfide bonds (July, 2021). | *[[Disulfide bonds]] are the most common protein crosslinks. About 23% of protein structures in the [[PDB]] have disulfide bonds (July, 2021). Example: Insulin [[9ins]] has 2 interchain and one intrachain disulfide bonds. | ||