7ekp: Difference between revisions
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==human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124== | ==human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124== | ||
<StructureSection load='7ekp' size='340' side='right'caption='[[7ekp]]' scene=''> | <StructureSection load='7ekp' size='340' side='right'caption='[[7ekp]], [[Resolution|resolution]] 2.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EKP FirstGlance]. <br> | <table><tr><td colspan='2'>[[7ekp]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EKP FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ekp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ekp OCA], [https://pdbe.org/7ekp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ekp RCSB], [https://www.ebi.ac.uk/pdbsum/7ekp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ekp ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=I33:7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide'>I33</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHRNA7, NACHRA7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ekp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ekp OCA], [https://pdbe.org/7ekp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ekp RCSB], [https://www.ebi.ac.uk/pdbsum/7ekp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ekp ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/ACHA7_HUMAN ACHA7_HUMAN]] 15q13.3 microdeletion syndrome. | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/ACHA7_HUMAN ACHA7_HUMAN]] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Liu S]] | [[Category: Liu, S]] | ||
[[Category: Sun D]] | [[Category: Sun, D]] | ||
[[Category: Tian C]] | [[Category: Tian, C]] | ||
[[Category: Zhao Y]] | [[Category: Zhao, Y]] | ||
[[Category: Alpha 7]] | |||
[[Category: Apo-form]] | |||
[[Category: Membrane protein]] | |||
[[Category: Nicotinic acetylcholine receptor]] | |||