1elo: Difference between revisions

Revision as of 15:15, 2 May 2008

ELONGATION FACTOR G WITHOUT NUCLEOTIDE

OverviewOverview

The crystal structure of Thermus thermophilus elongation factor G without guanine nucleotide was determined to 2.85 A. This GTPase has five domains with overall dimensions of 50 x 60 x 118 A. The GTP binding domain has a core common to other GTPases with a unique subdomain which probably functions as an intrinsic nucleotide exchange factor. Domains I and II are homologous to elongation factor Tu and their arrangement, both with and without GDP, is more similar to elongation factor Tu in complex with a GTP analogue than with GDP. Domains III and V show structural similarities to ribosomal proteins. Domain IV protrudes from the main body of the protein and has an extraordinary topology with a left-handed cross-over connection between two parallel beta-strands.

About this StructureAbout this Structure

1ELO is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

ReferenceReference

Three-dimensional structure of the ribosomal translocase: elongation factor G from Thermus thermophilus., AEvarsson A, Brazhnikov E, Garber M, Zheltonosova J, Chirgadze Y, al-Karadaghi S, Svensson LA, Liljas A, EMBO J. 1994 Aug 15;13(16):3669-77. PMID:8070397 Page seeded by OCA on Fri May 2 15:15:11 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1elo.gif|left|200px]]
- {{Structure
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-}}
 '''ELONGATION FACTOR G WITHOUT NUCLEOTIDE'''
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 [[Category: Svensson, L A.]]
 [[Category: Zheltonosova, J.]]
-[[Category: elongation factor]]
+[[Category: Elongation factor]]
-[[Category: gtp binding protein]]
+[[Category: Gtp binding protein]]
-[[Category: hydrolase]]
+[[Category: Hydrolase]]
-[[Category: ribosomal translocase]]
+[[Category: Ribosomal translocase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 15:15:11 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:05:05 2008''