2nx3: Difference between revisions

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==Structural and mechanistic changes along an engineered path from metallo to non-metallo KDO8P synthase==
==Structural and mechanistic changes along an engineered path from metallo to non-metallo KDO8P synthase==
<StructureSection load='2nx3' size='340' side='right' caption='[[2nx3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='2nx3' size='340' side='right'caption='[[2nx3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2nx3]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NX3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NX3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2nx3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NX3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NX3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1NT:(2R,4R,5R,6R,7R)-2,4,5,6,7-PENTAHYDROXY-2,8-BIS(PHOSPHONOOXY)OCTANOIC+ACID'>1NT</scene>, <scene name='pdbligand=A5P:ARABINOSE-5-PHOSPHATE'>A5P</scene>, <scene name='pdbligand=PEP:PHOSPHOENOLPYRUVATE'>PEP</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1NT:(2R,4R,5R,6R,7R)-2,4,5,6,7-PENTAHYDROXY-2,8-BIS(PHOSPHONOOXY)OCTANOIC+ACID'>1NT</scene>, <scene name='pdbligand=A5P:ARABINOSE-5-PHOSPHATE'>A5P</scene>, <scene name='pdbligand=PEP:PHOSPHOENOLPYRUVATE'>PEP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fwn|1fwn]], [[2nwr|2nwr]], [[2nws|2nws]], [[2nx1|2nx1]], [[2nxg|2nxg]], [[2nxh|2nxh]], [[2nxi|2nxi]], [[2nxk|2nxk]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fwn|1fwn]], [[2nwr|2nwr]], [[2nws|2nws]], [[2nx1|2nx1]], [[2nxg|2nxg]], [[2nxh|2nxh]], [[2nxi|2nxi]], [[2nxk|2nxk]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">kdsA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 "Aquifex aeolicus" Huber and Stetter 2001])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">kdsA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 "Aquifex aeolicus" Huber and Stetter 2001])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-deoxy-8-phosphooctulonate_synthase 3-deoxy-8-phosphooctulonate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.55 2.5.1.55] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3-deoxy-8-phosphooctulonate_synthase 3-deoxy-8-phosphooctulonate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.55 2.5.1.55] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nx3 OCA], [http://pdbe.org/2nx3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nx3 RCSB], [http://www.ebi.ac.uk/pdbsum/2nx3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nx3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nx3 OCA], [https://pdbe.org/2nx3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nx3 RCSB], [https://www.ebi.ac.uk/pdbsum/2nx3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nx3 ProSAT]</span></td></tr>
</table>
</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
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[[Category: Aquifex aeolicus huber and stetter 2001]]
[[Category: Aquifex aeolicus huber and stetter 2001]]
[[Category: 3-deoxy-8-phosphooctulonate synthase]]
[[Category: 3-deoxy-8-phosphooctulonate synthase]]
[[Category: Large Structures]]
[[Category: Gatti, D L]]
[[Category: Gatti, D L]]
[[Category: Kona, F]]
[[Category: Kona, F]]

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