2ndh: Difference between revisions
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==NMR solution structure of MAL/TIRAP TIR domain (C116A)== | ==NMR solution structure of MAL/TIRAP TIR domain (C116A)== | ||
<StructureSection load='2ndh' size='340' side='right' caption='[[2ndh]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2ndh' size='340' side='right'caption='[[2ndh]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ndh]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2ndh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NDH FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yp2|2yp2]], [[3ub2|3ub2]], [[4lqd|4lqd]], [[4fz5|4fz5]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yp2|2yp2]], [[3ub2|3ub2]], [[4lqd|4lqd]], [[4fz5|4fz5]]</div></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TIRAP, MAL ([ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TIRAP, MAL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ndh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ndh OCA], [https://pdbe.org/2ndh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ndh RCSB], [https://www.ebi.ac.uk/pdbsum/2ndh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ndh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/TIRAP_HUMAN TIRAP_HUMAN]] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.<ref>PMID:18292575</ref> <ref>PMID:19509286</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 2ndh" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2ndh" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[TIR domain-containing adapter protein|TIR domain-containing adapter protein]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Lavrencic, P]] | [[Category: Lavrencic, P]] | ||
[[Category: Mobli, M]] | [[Category: Mobli, M]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||