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==NMR structure of the C-terminal region of human eukaryotic elongation factor 1B== | ==NMR structure of the C-terminal region of human eukaryotic elongation factor 1B== | ||
<StructureSection load='2n51' size='340' side='right' caption='[[2n51]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2n51' size='340' side='right'caption='[[2n51]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2n51]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2n51]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N51 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N51 FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EEF1D, EF1D ([ | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EEF1D, EF1D ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n51 OCA], [https://pdbe.org/2n51 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n51 RCSB], [https://www.ebi.ac.uk/pdbsum/2n51 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n51 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/EF1D_HUMAN EF1D_HUMAN]] Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome. Isoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Feng, Y]] | [[Category: Feng, Y]] | ||
[[Category: Wu, H]] | [[Category: Wu, H]] | ||
[[Category: Guanine nucleotide exchange factor]] | [[Category: Guanine nucleotide exchange factor]] | ||
[[Category: Translation]] | [[Category: Translation]] | ||
Revision as of 18:39, 8 June 2021
NMR structure of the C-terminal region of human eukaryotic elongation factor 1BNMR structure of the C-terminal region of human eukaryotic elongation factor 1B
Structural highlights
Function[EF1D_HUMAN] Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome. Isoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). |
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