Intracellular receptors: Difference between revisions
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The structure of the complex of the ligand-binding domain of PR with RU486 - an abortion-inducing drug - shows the ligand bound at a similar location to other agonists or partial agonists with a flexible loop of PR being a possible entry route to the <scene name='78/780972/Cv/4'>binding site and several PR-RU486 interactions</scene> | The structure of the complex of the ligand-binding domain of PR with RU486 - an abortion-inducing drug - shows the ligand bound at a similar location to other agonists or partial agonists with a flexible loop of PR being a possible entry route to the <scene name='78/780972/Cv/4'>binding site and several PR-RU486 interactions</scene> | ||
*[[Androgen receptor]] | *[[Androgen receptor]] | ||
AR structure is composed of 5 domains: | |||
A/B: N-terminal regulatory domain contains activation function 1 (residues 101-370), activation function 5 (residues 360-485) and dimerization surface (residues 1-36 and 370-494). | |||
C: DNA binding domain (DBD) | |||
D: Hinge region between DBD and LBD | |||
E: Ligand binding domain (LBD) containing an <scene name='54/543362/Cv/3'>active site</scene> which binds intramolecularly the N-terminal FXXFL motif or coactivators with the same motif. | |||
F: C-terminal domain | |||
*[[Liver receptor homolog-1]]? | *[[Liver receptor homolog-1]]? | ||