Intracellular receptors: Difference between revisions

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Alexander Berchansky

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 <scene name='54/545859/Cv/3'>Structure</scene> of human FXR ligand-binding domain (deeppink) complex with non-steroidal agonist, nuclear receptor coactivator 1 peptide (cyan) and sulfate ions ([[3ruu]]).
 *[[Vitamin D receptor]]
-'''Vitamin D receptor''' (<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>) is a transcription factor.  Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression. The <scene name='56/562378/Vit_d_receptor_ligand/1'>vitamin D hormone</scene> (in green) binds to receptors in its target cells, controlling the synthesis of many different proteins involved in calcium transport and utilization. <scene name='51/517370/Cv/2'>Vitamin D hormone binding site</scene>. <scene name='51/517370/Cv/3'>Vitamin D hormone is located in deep pocket</scene>. VDR contains two domains: a <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> (see [[Nuclear receptors]]).  that binds to the hormone (grey) and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene> that binds to DNA. (Green and blue are two same VDR structures). It pairs up with a similar protein, 9-cis retinoic acid receptor (RXR), and together they bind to the DNA, activating synthesis in some cases and repressing it in others<ref>PMID:11425573</ref>.
+<scene name='56/562378/Vit_d_receptor_3m7r/3'>Vitamin D receptor (VDR)</scene> is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression. The <scene name='56/562378/Vit_d_receptor_ligand/1'>vitamin D hormone</scene> (in green) binds to receptors in its target cells, controlling the synthesis of many different proteins involved in calcium transport and utilization. <scene name='51/517370/Cv/2'>Vitamin D hormone binding site</scene>. <scene name='51/517370/Cv/3'>Vitamin D hormone is located in deep pocket</scene>. VDR contains two domains: a <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene>, that binds to the hormone (grey) and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene> that binds to DNA (green and blue are 2 same VDR structures). It pairs up with a similar protein, 9-cis retinoic acid receptor (RXR), and together they bind to the DNA, activating synthesis in some cases and repressing it in others.
 *[[Pregnane X receptor]]
 *[[Retinoid X receptor]]