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==Solution structure of human C-type lectin domain family 4 member D==
==Solution structure of human C-type lectin domain family 4 member D==
<StructureSection load='2ls8' size='340' side='right' caption='[[2ls8]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2ls8' size='340' side='right'caption='[[2ls8]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ls8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LS8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ls8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LS8 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CLEC4D, CLECSF8, MCL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CLEC4D, CLECSF8, MCL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ls8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ls8 OCA], [http://pdbe.org/2ls8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ls8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ls8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ls8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ls8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ls8 OCA], [https://pdbe.org/2ls8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ls8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ls8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ls8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CLC4D_HUMAN CLC4D_HUMAN]] Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells.<ref>PMID:14971047</ref>   
[[https://www.uniprot.org/uniprot/CLC4D_HUMAN CLC4D_HUMAN]] Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells.<ref>PMID:14971047</ref>   
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Almo, S C]]
[[Category: Almo, S C]]
[[Category: Bandaranayake, A D]]
[[Category: Bandaranayake, A D]]

Revision as of 13:17, 12 May 2021

Solution structure of human C-type lectin domain family 4 member DSolution structure of human C-type lectin domain family 4 member D

Structural highlights

2ls8 is a 1 chain structure with sequence from Human. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:CLEC4D, CLECSF8, MCL (HUMAN)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CLC4D_HUMAN] Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells.[1]

References

  1. ↑ Arce I, Martinez-Munoz L, Roda-Navarro P, Fernandez-Ruiz E. The human C-type lectin CLECSF8 is a novel monocyte/macrophage endocytic receptor. Eur J Immunol. 2004 Jan;34(1):210-20. PMID:14971047 doi:http://dx.doi.org/10.1002/eji.200324230
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