2b25: Difference between revisions

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<StructureSection load='2b25' size='340' side='right'caption='[[2b25]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='2b25' size='340' side='right'caption='[[2b25]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2b25]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B25 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B25 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2b25]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B25 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b25 OCA], [http://pdbe.org/2b25 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b25 RCSB], [http://www.ebi.ac.uk/pdbsum/2b25 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2b25 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b25 OCA], [https://pdbe.org/2b25 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b25 RCSB], [https://www.ebi.ac.uk/pdbsum/2b25 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b25 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TR61B_HUMAN TR61B_HUMAN]] Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (decephering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (decephering codons UCA, UCU, UCG or UCC).<ref>PMID:23097428</ref>   
[[https://www.uniprot.org/uniprot/TR61B_HUMAN TR61B_HUMAN]] Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (decephering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (decephering codons UCA, UCU, UCG or UCC).<ref>PMID:23097428</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 12:42, 5 May 2021

Human putative tRNA(1-methyladenosine)methyltransferaseHuman putative tRNA(1-methyladenosine)methyltransferase

Structural highlights

2b25 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TR61B_HUMAN] Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (decephering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (decephering codons UCA, UCU, UCG or UCC).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Chujo T, Suzuki T. Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs. RNA. 2012 Dec;18(12):2269-76. doi: 10.1261/rna.035600.112. Epub 2012 Oct 24. PMID:23097428 doi:http://dx.doi.org/10.1261/rna.035600.112

2b25, resolution 2.50Å

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