SARS-CoV-2 spike protein mutations: Difference between revisions
Eric Martz (talk | contribs) No edit summary |
Eric Martz (talk | contribs) No edit summary |
||
| Line 51: | Line 51: | ||
====Q677P/H==== | ====Q677P/H==== | ||
Sequence position 677 is close to the [[SARS-CoV-2 spike protein priming by furin|furin cleavage site]] at <span class="text-red">'''PRRAR'''</span> (681-684). The consequences of these mutations are under investigation. | Sequence position 677 is close to the [[SARS-CoV-2 spike protein priming by furin|furin cleavage site]] at <span class="text-red">'''PRRAR'''</span> (681-684). The consequences of these mutations are under investigation. | ||
====B.1.617==== | |||
The defining mutations in B.1.617 include L452R, P681R, and E484Q. '''L452R''' is present in B.1.429 the US "California" lineage, and confers resistance to convalescent serum antibodies<ref name="convalescent" />. '''P681R''' occurs in B.1.1.7, is in the [[SARS-CoV-2 spike protein priming by furin|furin cleavage site]] and is suspected of increasing contagiousness<ref name="617who" />. '''E484Q''' is similar to E484K, present in the "South African" lineage B.1.351 / 501Y.V2, and is thought to contribute to evasion of immunity<ref name="617who" />. | |||
===Vaccine Effectiveness Under Investigation=== | ===Vaccine Effectiveness Under Investigation=== | ||