SARS-CoV-2 spike protein mutations: Difference between revisions
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In February, 2021, mutations at '''position 677''' (Q677P, Q677H) were reported to have arisen independently (''convergent evolution'') in the south central and southwest USA, where they accounted for 28% (in Louisiana) and 11% (in New Mexico) of sequenced SARS-CoV-2 genomes by late January<ref name="s677">[https://www.medrxiv.org/content/10.1101/2021.02.12.21251658v2.full-text Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677], a preprint by Emma B. Hodcroft ''et al.'', posted February 14, 2021.</ref>. Q677H is present in lineage '''B.1.525'''<ref name="a." />. | In February, 2021, mutations at '''position 677''' (Q677P, Q677H) were reported to have arisen independently (''convergent evolution'') in the south central and southwest USA, where they accounted for 28% (in Louisiana) and 11% (in New Mexico) of sequenced SARS-CoV-2 genomes by late January<ref name="s677">[https://www.medrxiv.org/content/10.1101/2021.02.12.21251658v2.full-text Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677], a preprint by Emma B. Hodcroft ''et al.'', posted February 14, 2021.</ref>. Q677H is present in lineage '''B.1.525'''<ref name="a." />. | ||
'''B.1.617''' was first detected in October, 2020<ref name="617who">[https://www.who.int/docs/default-source/coronaviruse/situation-reports/20210427_weekly_epi_update_37.pdf COVID-19 Weekly Epidemiological Update for April 25, 2021] from the World Health Organization.</ref>. By the end of April, 2021, B.1.617 was predominant in India, where a devastating surge of COVID-19 was overwhelming hospitals<ref name="617who" /><ref name="617scientist">[https://www.the-scientist.com/news-opinion/what-scientists-know-about-the-b-1-617-coronavirus-variant-68733 What Scientists Know About the B.1.617 Coronavirus Variant] in ''The Scientist'', by Shauna Williams, May 3, 2021.</ref><ref name="617nature">[https://www.nature.com/articles/d41586-021-01059-y India’s massive COVID surge puzzles scientists], ''Nature'', by Smriti Mallapaty, April 21, 2021.</ref>. | '''B.1.617''' was first detected in October, 2020<ref name="617who">[https://www.who.int/docs/default-source/coronaviruse/situation-reports/20210427_weekly_epi_update_37.pdf COVID-19 Weekly Epidemiological Update for April 25, 2021] from the World Health Organization.</ref>. By the end of April, 2021, B.1.617 was predominant in India, where a devastating surge of COVID-19 was overwhelming hospitals<ref name="617who" /><ref name="617scientist">[https://www.the-scientist.com/news-opinion/what-scientists-know-about-the-b-1-617-coronavirus-variant-68733 What Scientists Know About the B.1.617 Coronavirus Variant] in ''The Scientist'', by Shauna Williams, May 3, 2021.</ref><ref name="617nature">[https://www.nature.com/articles/d41586-021-01059-y India’s massive COVID surge puzzles scientists], ''Nature'', by Smriti Mallapaty, April 21, 2021.</ref>. In addition to India, B.1.617 was identified in the USA, UK, and Singapore<ref name="617who" />. | ||
===Mutations Most Concerning=== | ===Mutations Most Concerning=== | ||