Hexokinase: Difference between revisions
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== Conformational change associated with substrate binding == | == Conformational change associated with substrate binding == | ||
When hexokinase binds to glucose (one of its two substrates), it exhibits induced fit. This means that in the open form of the enzyme, the binding site is not fully formed. Upon binding glucose, hexokinase switches into a closed form, excluding aqueous solvent from the substrate. This is illustrated here <scene name='45/452482/Induced_fit/ | When hexokinase binds to glucose (one of its two substrates), it exhibits induced fit. This means that in the open form of the enzyme, the binding site is not fully formed. Upon binding glucose, hexokinase switches into a closed form, excluding aqueous solvent from the substrate. This is illustrated here <scene name='45/452482/Induced_fit/2'>comparing the structures of free and glucose-bound hexokinase</scene>. | ||
<jmol> | <jmol> | ||
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<script>anim off; delay 0.5; model 1</script> | <script>anim off; delay 0.5; model 1</script> | ||
<text>Open</text> | <text>Open</text> | ||
<checked>true</checked> | |||
</item> | </item> | ||
<item> | <item> | ||
<script>anim off; delay 0.5; model 2</script> | <script>anim off; delay 0.5; model 2</script> | ||
<text>Close</text> | <text>Close</text> | ||
<checked>false</checked> | |||
</item> | </item> | ||
<item> | <item> | ||
<script>anim mode palindrome; anim on</script> | <script>anim mode palindrome; anim on</script> | ||
<text>Animate</text> | <text>Animate</text> | ||
<checked> | <checked>false</checked> | ||
</item> | </item> | ||
</jmolRadioGroup> | </jmolRadioGroup> | ||
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It is a bit easier to see the extent and nature of the changes in this <jmol> | It is a bit easier to see the extent and nature of the changes in this <jmol> | ||
<jmolLink> | <jmolLink> | ||
<script> script "/scripts/45/452482/Induced_fit/ | <script> script "/scripts/45/452482/Induced_fit/2.spt"; script "/wiki/images/a/a2/Storymorph.spt"; model 2; color background black; | ||
structures = [{1.1},{1.2}]; | structures = [{1.1},{1.2}]; | ||
domain2 = {82-210}; | domain2 = {82-210}; | ||