Sandbox GGC15: Difference between revisions

'''Human topo 1 is composed of 765 amino acids <ref name="Redinbo" />. The enzyme consist of 4 regions which are the NH2-terminal, core, linker, and COOH-terminal domains<ref name="Redinbo" />. The NH2-terminal  is approximately 210 residues long, it is highly charged, disordered, and contains few hydrophobic amino acids<ref name="Redinbo" />. The <scene name='78/781215/04_27_structure_cooh/1'>COOH-terminal</scene> domain is made up of residues 713 to 765 and contains the important amino aside <scene name='78/781215/04_27_structure_cooh_with_k/1'>Tyrosine 723</scene><ref name="Redinbo"/>. The location of the active site is at this amino acid<ref name="Redinbo" />. Residues 636 to 712 form the <scene name='78/781215/04_27_structure_linker/1'>Linker domain</scene> and they contribute to the enzyme catalytic activity but are not required<ref name="Redinbo" />. The core is divided into 3 subdomains: <scene name='78/781215/04_27_structure_core_sd1/1'>Core Sudomain 1</scene>[215-232 & 320-433], <scene name='78/781215/04_27_structure_core_sd2/1'>Core Subdomain 2</scene>[233-319], and <scene name='78/781215/04_27_structure_core_sd3/1'>Core Subdomain 3</scene>[434-635]<ref name="Redinbo"/>. The <scene name='78/781215/04_27_structure_core_cooh/1'>core and the COOH-terminal domains</scene> are very important for the catalytic activity<ref name="Redinbo" />.'''