Sandbox GGC14: Difference between revisions
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== Disease == | == Disease == | ||
As noted above, AChE is known for the blocking the signal of acetylcholine to the synaptic cleft. It plays important role in neural and muscular functions because it has been linked to neuronal apoptosis. The disease it is mainly known for being attributed to is Alzheimer's. Now it does not specifically cause this disease but it has been used to formulate medications and treatments that are already FDA approved. More so its inhibitor is what is used in the formulation of these treatments. | |||
Recall that acetylcholinesterase is also a toxin. In a study in which they were testing the effectiveness on mice the venom itself had the toxin. | |||
== Structural highlights == | == Structural highlights == | ||
===Scene 1=== | ===Scene 1=== | ||
This is a view of the <scene name='78/781216/00blue_ligands/2'>protein ligands</scene> that are binding to the enzyme. | |||
===Scene 2=== | ===Scene 2=== | ||
These are the <scene name='78/781216/00active_sites/1'>active binding sites</scene>. They are mutated points however the one deepest in a groove is the primary. | |||
===Scene 3=== | ===Scene 3=== | ||
This is the view of <scene name='78/781216/12_mutations/1'>mutations</scene> | |||
===Scene 4=== | ===Scene 4=== | ||
This | This is a view of <scene name='78/781216/12_binding_pockets/1'>binding pockets</scene> | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||