Sandbox GGC8: Difference between revisions
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==GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase)== | ==GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase)== | ||
<StructureSection load='3VEV' size='340' side='right' caption='GAPDH' scene=''> | <StructureSection load='3VEV' size='340' side='right' caption='GAPDH' scene=''> | ||
GAPDH is a protein known as Glyceraldehyde-3-Phosphate dehydrogenase. This protein is also known as the "housekeeping" protein of the cell, it consists of an average of 335 amino acids, and it is considered a heme. It is also considered a catalyst to break down glucose to create energy and to form carbon molecules. It has many functions in the cell and is considered very important. This protein is mostly expressed in the most vital organs, the liver, brain, kidneys, and heart. | GAPDH is a protein known as Glyceraldehyde-3-Phosphate dehydrogenase. This protein is also known as the "housekeeping" protein of the cell, it consists of an average of 335 amino acids, and it is considered a heme. It is also considered a catalyst to break down glucose to create energy and to form carbon molecules. It has many functions in the cell and is considered very important. This protein is mostly expressed in the most vital organs, the liver, brain, kidneys, and heart. | ||
== Function == | == Function == | ||
This Particular Protein Plays a big role in Glycolysis and activities in the nucleus. Glyceraldehyde-3-phosphate dehydrogenase is a very important enzyme that catalyzes the first step of the glycolysis pathway. This is done by converting D-glyceraldehyde-3-phosphate to 3-phospho-D glyceroyl phosphate. The catalytic reaction begins with the reactants of D-glyceraldehyde-3-phosphate, NAD+, and phosphate. This reaction then proceeds with the products of (2R)-3- phospho-D glyceroyl phosphate, H ion, and NADH. This reaction then proceeds in the glycolysis pathway and creates pyruvate from D-glyceraldehyde-3-phosphate. | This Particular Protein Plays a big role in Glycolysis and activities in the nucleus. Glyceraldehyde-3-phosphate dehydrogenase is a very important enzyme that catalyzes the first step of the glycolysis pathway. This is done by converting D-glyceraldehyde-3-phosphate to 3-phospho-D glyceroyl phosphate. The catalytic reaction begins with the reactants of D-glyceraldehyde-3-phosphate, NAD+, and phosphate. This reaction then proceeds with the products of (2R)-3- phospho-D glyceroyl phosphate, H ion, and NADH. This reaction then proceeds in the glycolysis pathway and creates pyruvate from D-glyceraldehyde-3-phosphate. | ||
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== Disease == | == Disease == | ||
GAPDH is expressed in many diseases and disorders. The main diseases and disorders that were confirmed from the expression of GAPDH are cancers and neurodegeneration. It has been confirmed that GAPDH is expressed in many cancers as its antiapoptotic function protects the tumor and cancerous cells in the body. The protection of those cells promotes tumorigeneses and their proliferation. GAPDH also protects against the shortening of telomeres. The shortening of telomeres is caused by chemotherapy. Furthermore, Oxidative Stress impairs protein function. By impairing GAPDH, it will cause the aging and the apoptosis of the cell. GAPDH can also manage to induce the biological aging of the cells which have been proved to maintain tumor growth and production. | GAPDH is expressed in many diseases and disorders. The main diseases and disorders that were confirmed from the expression of GAPDH are cancers and neurodegeneration. It has been confirmed that GAPDH is expressed in many cancers as its antiapoptotic function protects the tumor and cancerous cells in the body. The protection of those cells promotes tumorigeneses and their proliferation. GAPDH also protects against the shortening of telomeres. The shortening of telomeres is caused by chemotherapy. Furthermore, Oxidative Stress impairs protein function. By impairing GAPDH, it will cause the aging and the apoptosis of the cell. GAPDH can also manage to induce the biological aging of the cells which have been proved to maintain tumor growth and production. | ||
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== Relevance == | == Relevance == | ||
This protein is a component in many reactions and helps the eukaryote function in many ways at the cellular level. If affected by protein interactions, it will have a big impact on the eukaryote especially in the vital organs of the animal or human as it plays a big role in the vital organs. It will also lose its function and can be fatal to the human body as its important functions are disturbed and disrupted. | This protein is a component in many reactions and helps the eukaryote function in many ways at the cellular level. If affected by protein interactions, it will have a big impact on the eukaryote especially in the vital organs of the animal or human as it plays a big role in the vital organs. It will also lose its function and can be fatal to the human body as its important functions are disturbed and disrupted. | ||