Sandbox GGC15: Difference between revisions
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== Relevance == | == Relevance == | ||
'''Many anticancer drugs target topo 1 enzymes. This enzyme is the target of camptothecin (CPT) family of anticancer drugs<ref name="Redinbo" />. These drugs work by increasing the duration of the nicked intermediate in the <scene name='78/781215/04_28_revelance_cpt_bind/1'>topo I</scene> reaction <ref name="Redinbo" />. The stabilized intermediates prevent transcription and replication to continue in the cancer cells<ref name="Redinbo" />. This eventually leads to DNA damage and cell death<ref name="Redinbo" />.''' | '''Many anticancer drugs target topo 1 enzymes. This enzyme is the target of camptothecin (CPT) family of anticancer drugs<ref name="Redinbo" />. These drugs work by increasing the duration of the nicked intermediate in the <scene name='78/781215/04_28_revelance_cpt_bind/1'>topo I</scene> reaction <ref name="Redinbo" />. CPT enhances DNA breakage at sites with a guanine base at the +1 position on the DNA strand that is being cut<ref name="Redinbo" />. This is immediately downstream of the site that is being cleaved<ref name="Redinbo" />. The stabilized intermediates prevent transcription and replication to continue in the cancer cells<ref name="Redinbo" />. This eventually leads to DNA damage and cell death<ref name="Redinbo" />.''' | ||
[[Image:CPT and Enzyme.jpg]] <ref name="Redinbo" /> | [[Image:CPT and Enzyme.jpg]] <ref name="Redinbo" /> | ||