User:Jacob Holt/Sandbox 1: Difference between revisions

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== Introduction ==

[[Image:SCD1_rxn.png|~~450~~ px|right|thumb|Figure 1. Overall reaction completed by the SCD1 enzyme. It introduces a double bond between carbons 9 and 10 on the ligand Stearoyl CoA, converting it into Oleoyl CoA]]Stearyol CoA Desaturase (SCD1) functions as a lipogenic enzyme which is essential for fatty acid metabolism. SCD1 desaturates the sigma bond, within the 18-carbon acyl-CoA ligand, that attaches carbons 9 and 10<ref name="Bai">PMID: 26098370 </ref>. The primary role of SCD1 is to catalyze the biosynthesis of monounsaturated fatty acids (MUFAs) via saturated [https://en.wikipedia.org/wiki/Acyl-CoA acyl-CoAs] with an acyl chain length of 14-19 carbons<ref name="Paton">PMID: 19066317 </ref><ref name="Shen">PMID: 32470559 </ref>. Variations of the monounsaturated fatty acids function as precursors for the biosynthesis of [https://en.wikipedia.org/wiki/Phospholipid phospholipids], [https://en.wikipedia.org/wiki/Cholesteryl_ester cholesteryl esters], and [https://en.wikipedia.org/wiki/Triglyceride triglycerides]; therefore, SCD1 is a promising candidate for drug targeting<ref name="Bai" />.

[[Image:SCD1_rxn.png|500 px|right|thumb|Figure 1. Overall reaction completed by the SCD1 enzyme. It introduces a double bond between carbons 9 and 10 on the ligand Stearoyl CoA, converting it into Oleoyl CoA]]Stearyol CoA Desaturase (SCD1) functions as a lipogenic enzyme which is essential for fatty acid metabolism. SCD1 desaturates the sigma bond, within the 18-carbon acyl-CoA ligand, that attaches carbons 9 and 10<ref name="Bai">PMID: 26098370 </ref>. The primary role of SCD1 is to catalyze the biosynthesis of monounsaturated fatty acids (MUFAs) via saturated [https://en.wikipedia.org/wiki/Acyl-CoA acyl-CoAs] with an acyl chain length of 14-19 carbons<ref name="Paton">PMID: 19066317 </ref><ref name="Shen">PMID: 32470559 </ref>. Variations of the monounsaturated fatty acids function as precursors for the biosynthesis of [https://en.wikipedia.org/wiki/Phospholipid phospholipids], [https://en.wikipedia.org/wiki/Cholesteryl_ester cholesteryl esters], and [https://en.wikipedia.org/wiki/Triglyceride triglycerides]; therefore, SCD1 is a promising candidate for drug targeting<ref name="Bai" />.

== Structural Overview ==

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 == Introduction ==
-[[Image:SCD1_rxn.png|450 px|right|thumb|Figure 1. Overall reaction completed by the SCD1 enzyme. It introduces a double bond between carbons 9 and 10 on the ligand Stearoyl CoA, converting it into Oleoyl CoA]]Stearyol CoA Desaturase (SCD1) functions as a lipogenic enzyme which is essential for fatty acid metabolism. SCD1 desaturates the sigma bond, within the 18-carbon acyl-CoA ligand, that attaches carbons 9 and 10<ref name="Bai">PMID: 26098370 </ref>.  The primary role of SCD1 is to catalyze the biosynthesis of monounsaturated fatty acids (MUFAs) via saturated [https://en.wikipedia.org/wiki/Acyl-CoA acyl-CoAs] with an acyl chain length of 14-19 carbons<ref name="Paton">PMID: 19066317 </ref><ref name="Shen">PMID: 32470559 </ref>. Variations of the monounsaturated fatty acids function as precursors for the biosynthesis of [https://en.wikipedia.org/wiki/Phospholipid phospholipids], [https://en.wikipedia.org/wiki/Cholesteryl_ester cholesteryl esters], and [https://en.wikipedia.org/wiki/Triglyceride triglycerides]; therefore, SCD1 is a promising candidate for drug targeting<ref name="Bai" />.
+[[Image:SCD1_rxn.png|500 px|right|thumb|Figure 1. Overall reaction completed by the SCD1 enzyme. It introduces a double bond between carbons 9 and 10 on the ligand Stearoyl CoA, converting it into Oleoyl CoA]]Stearyol CoA Desaturase (SCD1) functions as a lipogenic enzyme which is essential for fatty acid metabolism. SCD1 desaturates the sigma bond, within the 18-carbon acyl-CoA ligand, that attaches carbons 9 and 10<ref name="Bai">PMID: 26098370 </ref>.  The primary role of SCD1 is to catalyze the biosynthesis of monounsaturated fatty acids (MUFAs) via saturated [https://en.wikipedia.org/wiki/Acyl-CoA acyl-CoAs] with an acyl chain length of 14-19 carbons<ref name="Paton">PMID: 19066317 </ref><ref name="Shen">PMID: 32470559 </ref>. Variations of the monounsaturated fatty acids function as precursors for the biosynthesis of [https://en.wikipedia.org/wiki/Phospholipid phospholipids], [https://en.wikipedia.org/wiki/Cholesteryl_ester cholesteryl esters], and [https://en.wikipedia.org/wiki/Triglyceride triglycerides]; therefore, SCD1 is a promising candidate for drug targeting<ref name="Bai" />.
 == Structural Overview ==