User:Jacob Holt/Sandbox 1: Difference between revisions

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== Structural Overview ==

[[Image:colorful2.jpg|352 px|thumb|right|Figure 3. Hydrophobicity of each of the 12 helices found in SCD. red, blue, yellow, and green represent helices found in the transmembrane region. Orange helices represent helices found on the surface of the membrane. Pale yellow helices represent the hydrophilic helices.]]SCD1 is a [https://en.wikipedia.org/wiki/Transmembrane ~~protein~~ transmembrane protein] (4 helices in membrane, 8 helices in cytoplasm, shown in figures 2 and 3) that acquires electrons via an electron transport chain which includes [https://en.wikipedia.org/wiki/Cytochrome_b5_reductase cytochrome b5 reductase] and [https://en.wikipedia.org/wiki/Cytochrome_b5 cytochrome b5]. The electrons are transferred via a ternary complex and accepted by SCD1 by the iron metal ions<ref name="Shen" />. SCD1 has 8 helices that are hydrophobic, 4 helices that are hydrophilic, and 3 helices that are amphipathic<ref name="Bai" /><ref name="Shen" />(figure 2).There are two Fe+2 metal ions within the structure of SCD1 that were determined by x-ray fluorescence chromatography [https://en.wikipedia.org/wiki/X-ray_fluorescence x-ray fluorescense]<ref name="Shen" />. These ions are believed to be the activators of the catalytic molecule to allow for the desaturation reaction to occur within the enzyme.

[[Image:colorful2.jpg|352 px|thumb|right|Figure 3. Hydrophobicity of each of the 12 helices found in SCD. red, blue, yellow, and green represent helices found in the transmembrane region. Orange helices represent helices found on the surface of the membrane. Pale yellow helices represent the hydrophilic helices.]]SCD1 is a [https://en.wikipedia.org/wiki/Transmembrane transmembrane protein] (4 helices in membrane, 8 helices in cytoplasm, shown in figures 2 and 3) that acquires electrons via an electron transport chain which includes [https://en.wikipedia.org/wiki/Cytochrome_b5_reductase cytochrome b5 reductase] and [https://en.wikipedia.org/wiki/Cytochrome_b5 cytochrome b5]. The electrons are transferred via a ternary complex and accepted by SCD1 by the iron metal ions<ref name="Shen" />. SCD1 has 8 helices that are hydrophobic, 4 helices that are hydrophilic, and 3 helices that are amphipathic<ref name="Bai" /><ref name="Shen" />(figure 2).There are two Fe+2 metal ions within the structure of SCD1 that were determined by x-ray fluorescence chromatography [https://en.wikipedia.org/wiki/X-ray_fluorescence x-ray fluorescense]<ref name="Shen" />. These ions are believed to be the activators of the catalytic molecule to allow for the desaturation reaction to occur within the enzyme.

[[Image:screenshotSCD.png|460 px|left|thumb|Figure 2. Colored helices based on hydrophobicity. Red, green, yellow, and blue represent the transmembrane helices. Orange represents the helices found on the surface of the membrane, and tan represents the helices found in the cytoplasm.]]

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 == Structural Overview ==
-[[Image:colorful2.jpg|352 px|thumb|right|Figure 3. Hydrophobicity of each of the 12 helices found in SCD.  red, blue, yellow, and green represent helices found in the transmembrane region.  Orange helices represent helices found on the surface of the membrane.  Pale yellow helices represent the hydrophilic helices.]]SCD1 is a [https://en.wikipedia.org/wiki/Transmembrane protein transmembrane protein] (4 helices in membrane, 8 helices in cytoplasm, shown in figures 2 and 3) that acquires electrons via an electron transport chain which includes [https://en.wikipedia.org/wiki/Cytochrome_b5_reductase cytochrome b5 reductase] and [https://en.wikipedia.org/wiki/Cytochrome_b5 cytochrome b5].  The electrons are transferred via a ternary complex and accepted by SCD1 by the iron metal ions<ref name="Shen" />.  SCD1 has 8 helices that are hydrophobic, 4 helices that are hydrophilic, and 3 helices that are amphipathic<ref name="Bai" /><ref name="Shen" />(figure 2).There are two Fe+2 metal ions within the structure of SCD1 that were determined by x-ray fluorescence chromatography [https://en.wikipedia.org/wiki/X-ray_fluorescence x-ray fluorescense]<ref name="Shen" />.  These ions are believed to be the activators of the catalytic molecule to allow for the desaturation reaction to occur within the enzyme.
+[[Image:colorful2.jpg|352 px|thumb|right|Figure 3. Hydrophobicity of each of the 12 helices found in SCD.  red, blue, yellow, and green represent helices found in the transmembrane region.  Orange helices represent helices found on the surface of the membrane.  Pale yellow helices represent the hydrophilic helices.]]SCD1 is a [https://en.wikipedia.org/wiki/Transmembrane transmembrane protein] (4 helices in membrane, 8 helices in cytoplasm, shown in figures 2 and 3) that acquires electrons via an electron transport chain which includes [https://en.wikipedia.org/wiki/Cytochrome_b5_reductase cytochrome b5 reductase] and [https://en.wikipedia.org/wiki/Cytochrome_b5 cytochrome b5].  The electrons are transferred via a ternary complex and accepted by SCD1 by the iron metal ions<ref name="Shen" />.  SCD1 has 8 helices that are hydrophobic, 4 helices that are hydrophilic, and 3 helices that are amphipathic<ref name="Bai" /><ref name="Shen" />(figure 2).There are two Fe+2 metal ions within the structure of SCD1 that were determined by x-ray fluorescence chromatography [https://en.wikipedia.org/wiki/X-ray_fluorescence x-ray fluorescense]<ref name="Shen" />.  These ions are believed to be the activators of the catalytic molecule to allow for the desaturation reaction to occur within the enzyme.
 [[Image:screenshotSCD.png|460 px|left|thumb|Figure 2. Colored helices based on hydrophobicity. Red, green, yellow, and blue represent the transmembrane helices.  Orange represents the helices found on the surface of the membrane, and tan represents the helices found in the cytoplasm.]]