1e79: Difference between revisions

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Revision as of 14:45, 2 May 2008

File:1e79.gif

1e79, resolution 2.40Å ()

Ligands:

, , , , ,

Activity:

H(+)-transporting two-sector ATPase, with EC number 3.6.3.14

Related:

1bmf, 1cow, 1e1q, 1e1r, 1efr, 1nbm, 1qo1

Evolutionary conservation:

Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

BOVINE F1-ATPASE INHIBITED BY DCCD (DICYCLOHEXYLCARBODIIMIDE)

OverviewOverview

The central stalk in ATP synthase, made of gamma, delta and epsilon subunits in the mitochondrial enzyme, is the key rotary element in the enzyme's catalytic mechanism. The gamma subunit penetrates the catalytic (alpha beta)(3) domain and protrudes beneath it, interacting with a ring of c subunits in the membrane that drives rotation of the stalk during ATP synthesis. In other crystals of F(1)-ATPase, the protrusion was disordered, but with crystals of F(1)-ATPase inhibited with dicyclohexylcarbodiimide, the complete structure was revealed. The delta and epsilon subunits interact with a Rossmann fold in the gamma subunit, forming a foot. In ATP synthase, this foot interacts with the c-ring and couples the transmembrane proton motive force to catalysis in the (alpha beta)(3) domain.

About this StructureAbout this Structure

1E79 is a Protein complex structure of sequences from Bos taurus. The following page contains interesting information on the relation of 1E79 with [ATP Synthase]. Full crystallographic information is available from OCA.

ReferenceReference

The structure of the central stalk in bovine F(1)-ATPase at 2.4 A resolution., Gibbons C, Montgomery MG, Leslie AG, Walker JE, Nat Struct Biol. 2000 Nov;7(11):1055-61. PMID:11062563 Page seeded by OCA on Fri May 2 14:45:13 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1e79.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1e79 |SIZE=350|CAPTION= <scene name='initialview01'>1e79</scene>, resolution 2.4&Aring;
+The line below this paragraph, containing "STRUCTURE_1e79", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=AT1:Atp+Binding+Site+For+Chain+A'>AT1</scene>, <scene name='pdbsite=AT2:Adp+Binding+Site+For+Chain+B'>AT2</scene>, <scene name='pdbsite=AT3:Atp+Binding+Site+For+Chain+C'>AT3</scene>, <scene name='pdbsite=AT4:Adp+Binding+Site+For+Chain+D'>AT4</scene>, <scene name='pdbsite=AT5:Adp+Binding+Site+For+Chain+F'>AT5</scene>, <scene name='pdbsite=CAT:The+Carboxylate+Group+Of+Glutamic+Aci+Residue+Is+Believe+...'>CAT</scene> and <scene name='pdbsite=PLP:LYS+Within+The+P-Loop+(Phosphate+Binding)+Motif,+Gxxxxgkt/S'>PLP</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GLH:N-5-CYCLOHEXYL-N-5-[(CYCLOHEXYLAMINO)CARBONYL]GLUTAMINE'>GLH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1e79|  PDB=1e79  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e79 OCA], [http://www.ebi.ac.uk/pdbsum/1e79 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1e79 RCSB]</span>
-}}
 '''BOVINE F1-ATPASE INHIBITED BY DCCD (DICYCLOHEXYLCARBODIIMIDE)'''
@@ Line 25: / Line 22: @@
 [[Category: ATP Synthase]]
 [[Category: Bos taurus]]
-[[Category: H(+)-transporting two-sector ATPase]]
 [[Category: Protein complex]]
 [[Category: Gibbons, C.]]
@@ Line 31: / Line 27: @@
 [[Category: Montgomery, M G.]]
 [[Category: Walker, J E.]]
-[[Category: atp phosphorylase]]
+[[Category: Atp phosphorylase]]
-[[Category: atp phosphorylase (h+ transporting)]]
+[[Category: Atp synthase]]
-[[Category: atp synthase]]
+[[Category: Central stalk]]
-[[Category: central stalk]]
+[[Category: Dccd]]
-[[Category: dccd]]
+[[Category: Dicyclohexylcarbodiimide]]
-[[Category: dicyclohexylcarbodiimide]]
+[[Category: F1-atpase]]
-[[Category: f1-atpase]]
+[[Category: F1fo atp synthase]]
-[[Category: f1fo atp synthase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:45:13 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:56:44 2008''