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==HCV NS3-4a protease domain with ketoamide inhibitor narlaprevir== | ==HCV NS3-4a protease domain with ketoamide inhibitor narlaprevir== | ||
<StructureSection load='3lon' size='340' side='right' caption='[[3lon]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='3lon' size='340' side='right'caption='[[3lon]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3lon]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3lon]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1a Hepatitis c virus subtype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LON FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=NNA:(1R,2S,5S)-3-[N-({1-[(tert-butylsulfonyl)methyl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-N-{(1S)-1-[(1R)-2-(cyclopropylamino)-1-hydroxy-2-oxoethyl]pentyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide'>NNA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=NNA:(1R,2S,5S)-3-[N-({1-[(tert-butylsulfonyl)methyl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-N-{(1S)-1-[(1R)-2-(cyclopropylamino)-1-hydroxy-2-oxoethyl]pentyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide'>NNA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NS3 ([ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NS3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=31646 Hepatitis C virus subtype 1a])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lon OCA], [https://pdbe.org/3lon PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lon RCSB], [https://www.ebi.ac.uk/pdbsum/3lon PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lon ProSAT]</span></td></tr> | ||
</table> | </table> | ||
==See Also== | |||
*[[Virus protease 3D structures|Virus protease 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Hepatitis c virus subtype 1a]] | [[Category: Hepatitis c virus subtype 1a]] | ||
[[Category: Large Structures]] | |||
[[Category: Prongay, A J]] | [[Category: Prongay, A J]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
Revision as of 09:49, 14 April 2021
HCV NS3-4a protease domain with ketoamide inhibitor narlaprevirHCV NS3-4a protease domain with ketoamide inhibitor narlaprevir
Structural highlights
See Also |
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Hepatitis c virus subtype 1a
- Large Structures
- Prongay, A J
- Atp-binding
- Capsid protein
- Envelope protein
- Helicase
- Hepatitis c virus
- Host membrane
- Hydrolase
- Macrocyclic ketoamide inhibitor
- Membrane
- Ns3 protease domain
- Nucleotide-binding
- Rna replication
- Serine protease
- Transmembrane
- Viral protein
- Viral protein-inhibitor complex
- Virion