1e4j: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1e4j.gif|left|200px]] | [[Image:1e4j.gif|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_1e4j", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
| | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| | or leave the SCENE parameter empty for the default display. | ||
--> | |||
{{STRUCTURE_1e4j| PDB=1e4j | SCENE= }} | |||
}} | |||
'''CRYSTAL STRUCTURE OF THE SOLUBLE HUMAN FC-GAMMA RECEPTOR III''' | '''CRYSTAL STRUCTURE OF THE SOLUBLE HUMAN FC-GAMMA RECEPTOR III''' | ||
| Line 28: | Line 25: | ||
[[Category: Jacob, U.]] | [[Category: Jacob, U.]] | ||
[[Category: Sondermann, P.]] | [[Category: Sondermann, P.]] | ||
[[Category: | [[Category: Cd16]] | ||
[[Category: | [[Category: Fc]] | ||
[[Category: | [[Category: Gamma]] | ||
[[Category: | [[Category: Igg]] | ||
[[Category: | [[Category: Receptor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:39:10 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 14:39, 2 May 2008
CRYSTAL STRUCTURE OF THE SOLUBLE HUMAN FC-GAMMA RECEPTOR III
OverviewOverview
The immune response depends on the binding of opsonized antigens to cellular Fc receptors and the subsequent initiation of various cellular effector functions of the immune system. Here we describe the crystal structures of a soluble Fc gamma receptor (sFc gammaRIII, CD16), an Fc fragment from human IgG1 (hFc1) and their complex. In the 1:1 complex the receptor binds to the two halves of the Fc fragment in contact with residues of the C gamma2 domains and the hinge region. Upon complex formation the angle between the two sFc gammaRIII domains increases significantly and the Fc fragment opens asymmetrically. The high degree of amino acid conservation between sFc gammaRIII and other Fc receptors, and similarly between hFc1 and related immunoglobulins, suggest similar structures and modes of association. Thus the described structure is a model for immune complex recognition and helps to explain the vastly differing affinities of other Fc gammaR-IgG complexes and the Fc epsilonRI alpha-IgE complex.
About this StructureAbout this Structure
1E4J is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex., Sondermann P, Huber R, Oosthuizen V, Jacob U, Nature. 2000 Jul 20;406(6793):267-73. PMID:10917521 Page seeded by OCA on Fri May 2 14:39:10 2008