1id1: Difference between revisions
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<StructureSection load='1id1' size='340' side='right'caption='[[1id1]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='1id1' size='340' side='right'caption='[[1id1]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1id1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ID1 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[1id1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ID1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ID1 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1id1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1id1 OCA], [https://pdbe.org/1id1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1id1 RCSB], [https://www.ebi.ac.uk/pdbsum/1id1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1id1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/KCH_ECOLI KCH_ECOLI]] K(+)-specific ion channel. May play a role in the defense against osmotic shock.<ref>PMID:8170937</ref> <ref>PMID:12912904</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 10:40, 7 April 2021
CRYSTAL STRUCTURE OF THE RCK DOMAIN FROM E.COLI POTASSIUM CHANNELCRYSTAL STRUCTURE OF THE RCK DOMAIN FROM E.COLI POTASSIUM CHANNEL
Structural highlights
Function[KCH_ECOLI] K(+)-specific ion channel. May play a role in the defense against osmotic shock.[1] [2] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe intracellular C-terminal domain structure of a six-transmembrane K+ channel from Escherichia coli has been solved by X-ray crystallography at 2.4 A resolution. The structure is representative of a broad class of domains/proteins that regulate the conductance of K+ (here referred to as RCK domains) in prokaryotic K+ transporters and K+ channels. The RCK domain has a Rossmann-fold topology with unique positions, not commonly conserved among Rossmann-fold proteins, composing a well-conserved salt bridge and a hydrophobic dimer interface. Structure-based amino acid sequence alignments and mutational analysis are used to demonstrate that an RCK domain is also present and is an important component of the gating machinery in eukaryotic large-conductance Ca2+ activated K+ channels. Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel.,Jiang Y, Pico A, Cadene M, Chait BT, MacKinnon R Neuron. 2001 Mar;29(3):593-601. PMID:11301020[3] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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