1e3o: Difference between revisions

Revision as of 14:37, 2 May 2008

CRYSTAL STRUCTURE OF OCT-1 POU DIMER BOUND TO MORE

OverviewOverview

Two crystal structures of Oct-1 POU domain bound to DNA provide a rationale for differential, conformation-dependent recruitment of transcription cofactors. The POU-homeo and POU-specific subdomains of Oct-1 contain two different nonoverlapping pairs of surface patches that are capable of forming unrelated protein-protein interfaces. Members of the POU factor family contain one or two conserved sequence motifs in the interface that are known to be phosphorylated, as noted for Oct-1 and Pit-1. Modeling of Oct-4 reveals the unique case where the same conserved sequence is located in both interfaces. Our studies provide the basis for two distinct dimeric POU factor arrangements that are dictated by the architecture of each DNA response element. We suggest interface swapping in dimers could be a general mechanism of modulating the activity of transcription factors.

About this StructureAbout this Structure

1E3O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Differential dimer activities of the transcription factor Oct-1 by DNA-induced interface swapping., Remenyi A, Tomilin A, Pohl E, Lins K, Philippsen A, Reinbold R, Scholer HR, Wilmanns M, Mol Cell. 2001 Sep;8(3):569-80. PMID:11583619 Page seeded by OCA on Fri May 2 14:37:23 2008

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OCA

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 [[Image:1e3o.gif|left|200px]]
- {{Structure
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 '''CRYSTAL STRUCTURE OF OCT-1 POU DIMER BOUND TO MORE'''
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 [[Category: Tomilin, A.]]
 [[Category: Wilmanns, M.]]
-[[Category: dimer]]
+[[Category: Dimer]]
-[[Category: dna binding]]
+[[Category: Dna binding]]
-[[Category: pou domain]]
+[[Category: Pou domain]]
-[[Category: transcription factor]]
+[[Category: Transcription factor]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:37:23 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:54:27 2008''