Antibody: Difference between revisions
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'''Antibodies''', also known as '''Immunoglobulins''' (Ig) are gamma globulin proteins, primarily found in the blood of vertebrates. These [[glycoproteins]] serve as a critical component of the immune system when the host fails to activate alternative compliment pathways or phagocytic cells in response to invading microorganisms or other [http://en.wikipedia.org/wiki/Antigen antigens]. The incredible specificity with which immunoglobulins bind to an antigen is based upon structural complementarity between the antigen and antibody <scene name='Antibody/1hzh_heavy_chains/1'>heavy </scene>and <scene name='Antibody/1hzh_light_chains/1'>light chains </scene>. It is this specificity that has made <scene name='Antibody/1hzh_starting_scene/3'>antibodies</scene> a critical component in laboratory and medical research. <br /> | '''Antibodies''', also known as '''Immunoglobulins''' (Ig) are gamma globulin proteins, primarily found in the blood of vertebrates. These [[glycoproteins]] serve as a critical component of the immune system when the host fails to activate alternative compliment pathways or phagocytic cells in response to invading microorganisms or other [http://en.wikipedia.org/wiki/Antigen antigens]. The incredible specificity with which immunoglobulins bind to an antigen is based upon structural complementarity between the antigen and antibody <scene name='Antibody/1hzh_heavy_chains/1'>heavy </scene>and <scene name='Antibody/1hzh_light_chains/1'>light chains </scene>. It is this specificity that has made <scene name='Antibody/1hzh_starting_scene/3'>antibodies</scene> a critical component in laboratory and medical research. <br /> | ||
'''Humanized mouse antibody (hmFab)''' is a modified mFab which resembles more hFab.<br /> | '''Humanized mouse antibody (hmFab)''' is a modified mFab which resembles more hFab.<br /> | ||
'''Broadly neutralizing Fab''' and '''Neutralizing Fab''' are anti- | '''Broadly neutralizing Fab''' and '''Neutralizing Fab''' are anti-virus Fab. '''Intrabody''' is intracellular antibody. '''Sybody''' is synthetic antibody. <br /> | ||
'''Lama antibodies''' or '''nanobodies''' or '''camelid''' or '''VHH''' are natural single-domain antibodies containing just the heavy chain.<br /> | '''Lama antibodies''' or '''nanobodies''' or '''camelid''' or '''VHH''' are natural single-domain antibodies containing just the heavy chain.<br /> | ||
'''scFv''' is a single chain variable fragment in a fusion protein of the variable regions of the heavy and light chains of immunoglobulin. | '''scFv''' is a single chain variable fragment in a fusion protein of the variable regions of the heavy and light chains of immunoglobulin. | ||