2jhp: Difference between revisions
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<StructureSection load='2jhp' size='340' side='right'caption='[[2jhp]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='2jhp' size='340' side='right'caption='[[2jhp]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2jhp]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2jhp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Btv_10 Btv 10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JHP FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jh8|2jh8]], [[2jh9|2jh9]], [[2jha|2jha]], [[2jhc|2jhc]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jh8|2jh8]], [[2jh9|2jh9]], [[2jha|2jha]], [[2jhc|2jhc]]</div></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhp OCA], [https://pdbe.org/2jhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jhp RCSB], [https://www.ebi.ac.uk/pdbsum/2jhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jhp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/VP4_BTV10 VP4_BTV10]] The VP4 protein is one of the five proteins (with VP1, VP3, VP6 and VP7) which form the inner capsid of the virus. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</div> | </div> | ||
<div class="pdbe-citations 2jhp" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2jhp" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 14:27, 31 March 2021
The structure of bluetongue virus VP4 reveals a multifunctional RNA- capping production-lineThe structure of bluetongue virus VP4 reveals a multifunctional RNA- capping production-line
Structural highlights
Function[VP4_BTV10] The VP4 protein is one of the five proteins (with VP1, VP3, VP6 and VP7) which form the inner capsid of the virus. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedEukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure. Bluetongue virus VP4 is an RNA-capping assembly line.,Sutton G, Grimes JM, Stuart DI, Roy P Nat Struct Mol Biol. 2007 May;14(5):449-51. Epub 2007 Apr 8. PMID:17417654[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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