1dzl: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1dzl.gif|left|200px]] | [[Image:1dzl.gif|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_1dzl", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
| | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| | or leave the SCENE parameter empty for the default display. | ||
--> | |||
{{STRUCTURE_1dzl| PDB=1dzl | SCENE= }} | |||
}} | |||
'''L1 PROTEIN OF HUMAN PAPILLOMAVIRUS 16''' | '''L1 PROTEIN OF HUMAN PAPILLOMAVIRUS 16''' | ||
| Line 29: | Line 26: | ||
[[Category: Goldberge, I.]] | [[Category: Goldberge, I.]] | ||
[[Category: Harrison, S C.]] | [[Category: Harrison, S C.]] | ||
[[Category: | [[Category: Icosahedral]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:28:34 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 14:28, 2 May 2008
L1 PROTEIN OF HUMAN PAPILLOMAVIRUS 16
OverviewOverview
The papillomavirus major late protein, L1, forms the pentameric assembly unit of the viral shell. Recombinant HPV16 L1 pentamers assemble in vitro into capsid-like structures, and truncation of ten N-terminal residues leads to a homogeneous preparation of 12-pentamer, icosahedral particles. X-ray crystallographic analysis of these particles at 3.5 A resolution shows that L1 closely resembles VP1 from polyomaviruses. Surface loops contain the sites of sequence variation among HPV types and the locations of dominant neutralizing epitopes. The ease with which small virus-like particles may be obtained from L1 expressed in E. coli makes them attractive candidate components of a papillomavirus vaccine. Their crystal structure also provides a starting point for future vaccine design.
About this StructureAbout this Structure
1DZL is a Single protein structure of sequence from Human papillomavirus type 16. Full crystallographic information is available from OCA.
ReferenceReference
Structure of small virus-like particles assembled from the L1 protein of human papillomavirus 16., Chen XS, Garcea RL, Goldberg I, Casini G, Harrison SC, Mol Cell. 2000 Mar;5(3):557-67. PMID:10882140 Page seeded by OCA on Fri May 2 14:28:34 2008