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Acyl-coenzyme A Cholesterol Acyltransferase
References
Student Contributors
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==Acyl-coenzyme A Cholesterol Acyltransferase | ==Acyl-coenzyme A Cholesterol Acyltransferase== | ||
<StructureSection load='6p2p' size='340' side='right' caption='ACAT' scene='87/877604/Practice/1'> | <StructureSection load='6p2p' size='340' side='right' caption='ACAT' scene='87/877604/Practice/1'> | ||
<ref name=”Ransey”>PMID:28504306</ref> | <ref name=”Ransey”>PMID:28504306</ref> | ||
==Introduction== | ==Introduction== | ||
Acyl-Coenzyme A Cholesterol Acyltransferase (ACAT), or also known as Sterol | |||
[[Image:Screen Shot 2021-03-16 at 3.11.39 PM.png|400 px|right|thumb|Figure 1. The coolest image of this protein EVAH!!!”]] | [[Image:Screen Shot 2021-03-16 at 3.11.39 PM.png|400 px|right|thumb|Figure 1. The coolest image of this protein EVAH!!!”]] | ||
Revision as of 22:39, 23 March 2021
Acyl-coenzyme A Cholesterol AcyltransferaseAcyl-coenzyme A Cholesterol Acyltransferase
IntroductionAcyl-Coenzyme A Cholesterol Acyltransferase (ACAT), or also known as Sterol  FunctionACAT is an important enzyme that catalyzes the esterification of cholesterol to form cholesterol esters. SOAT article [2] ACAT article [3] Diseaseatherosclerosis, Alzheimer's Disease RelevanceStructural highlights
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ReferencesReferences
- ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
- ↑ Guan C, Niu Y, Chen SC, Kang Y, Wu JX, Nishi K, Chang CCY, Chang TY, Luo T, Chen L. Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor. Nat Commun. 2020 May 18;11(1):2478. doi: 10.1038/s41467-020-16288-4. PMID:32424158 doi:http://dx.doi.org/10.1038/s41467-020-16288-4
- ↑ Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N. Structural basis for catalysis and substrate specificity of human ACAT1. Nature. 2020 May;581(7808):333-338. doi: 10.1038/s41586-020-2290-0. Epub 2020 May, 13. PMID:32433614 doi:http://dx.doi.org/10.1038/s41586-020-2290-0
Student ContributorsStudent Contributors
- Tori Templin
- Haylie Moehlenkamp
- Megan Fleshman