2hdq: Difference between revisions

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==AmpC beta-lactamase in complex with 2-carboxythiophene==
==AmpC beta-lactamase in complex with 2-carboxythiophene==
<StructureSection load='2hdq' size='340' side='right' caption='[[2hdq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='2hdq' size='340' side='right'caption='[[2hdq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2hdq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HDQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2hdq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HDQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C21:THIOPHENE-2-CARBOXYLIC+ACID'>C21</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C21:THIOPHENE-2-CARBOXYLIC+ACID'>C21</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2hdr|2hdr]], [[2hds|2hds]], [[2hdu|2hdu]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hdr|2hdr]], [[2hds|2hds]], [[2hdu|2hdu]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ampC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ampC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hdq OCA], [http://pdbe.org/2hdq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hdq RCSB], [http://www.ebi.ac.uk/pdbsum/2hdq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2hdq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hdq OCA], [https://pdbe.org/2hdq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hdq RCSB], [https://www.ebi.ac.uk/pdbsum/2hdq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hdq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI]] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.  
[[https://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI]] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Beta-lactamase|Beta-lactamase]]
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Beta-lactamase]]
[[Category: Beta-lactamase]]
[[Category: Ecoli]]
[[Category: Ecoli]]
[[Category: Large Structures]]
[[Category: Babaoglu, K]]
[[Category: Babaoglu, K]]
[[Category: Shoichet, B K]]
[[Category: Shoichet, B K]]
[[Category: Fragment-based beta-lactamase ampc drug design]]
[[Category: Fragment-based beta-lactamase ampc drug design]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

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