6oon: Difference between revisions
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==RNA | ==Human Argonaute4 bound to guide RNA== | ||
<StructureSection load='6oon' size='340' side='right'caption='[[6oon]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='6oon' size='340' side='right'caption='[[6oon]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6oon]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6oon]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ ] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OON FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AGO4, EIF2C4, KIAA1567 ([ | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AGO4, EIF2C4, KIAA1567 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oon OCA], [https://pdbe.org/6oon PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oon RCSB], [https://www.ebi.ac.uk/pdbsum/6oon PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oon ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/AGO4_HUMAN AGO4_HUMAN]] Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).[HAMAP-Rule:MF_03033]<ref>PMID:15337849</ref> <ref>PMID:18552826</ref> <ref>PMID:18771919</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6oon" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6oon" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Argonaute 3D structures|Argonaute 3D structures]] | |||
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> |