2fvz: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:


==Human Inositol Monophosphosphatase 2==
==Human Inositol Monophosphosphatase 2==
<StructureSection load='2fvz' size='340' side='right' caption='[[2fvz]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='2fvz' size='340' side='right'caption='[[2fvz]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2fvz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FVZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2fvz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FVZ FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IMPA2, IMP.18P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IMPA2, IMP.18P ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvz OCA], [http://pdbe.org/2fvz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fvz RCSB], [http://www.ebi.ac.uk/pdbsum/2fvz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fvz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvz OCA], [https://pdbe.org/2fvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fvz RCSB], [https://www.ebi.ac.uk/pdbsum/2fvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fvz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IMPA2_HUMAN IMPA2_HUMAN]] Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.<ref>PMID:17068342</ref>   
[[https://www.uniprot.org/uniprot/IMPA2_HUMAN IMPA2_HUMAN]] Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.<ref>PMID:17068342</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 22: Line 22:


==See Also==
==See Also==
*[[Inositol Monophosphatase|Inositol Monophosphatase]]
*[[Inositol monophosphatase 3D structures|Inositol monophosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 29: Line 29:
[[Category: Human]]
[[Category: Human]]
[[Category: Inositol-phosphate phosphatase]]
[[Category: Inositol-phosphate phosphatase]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C]]
[[Category: Arrowsmith, C]]
[[Category: Berg, S Van Den]]
[[Category: Berg, S Van Den]]

Revision as of 18:34, 3 March 2021

Human Inositol Monophosphosphatase 2Human Inositol Monophosphosphatase 2

Structural highlights

2fvz is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:IMPA2, IMP.18P (HUMAN)
Activity:Inositol-phosphate phosphatase, with EC number 3.1.3.25
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[IMPA2_HUMAN] Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Ohnishi T, Ohba H, Seo KC, Im J, Sato Y, Iwayama Y, Furuichi T, Chung SK, Yoshikawa T. Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. J Biol Chem. 2007 Jan 5;282(1):637-46. Epub 2006 Oct 26. PMID:17068342 doi:http://dx.doi.org/10.1074/jbc.M604474200

2fvz, resolution 2.40Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2fvz&oldid=3364335"