6tqk: Difference between revisions

<table><tr><td colspan='2'>[[6tqk]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TQK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TQK FirstGlance]. <br>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tqk OCA], [http://pdbe.org/6tqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tqk RCSB], [http://www.ebi.ac.uk/pdbsum/6tqk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tqk ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/UROM_HUMAN UROM_HUMAN]] UMOD-related autosomal dominant tubulointerstitial kidney disease. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  

[[http://www.uniprot.org/uniprot/UROM_HUMAN UROM_HUMAN]] Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed:3498215). Facilitates neutrophil migration across renal epithelia (PubMed:20798515).<ref>PMID:20798515</ref> <ref>PMID:3498215</ref>  In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.[UniProtKB:Q91X17]