1dt6: Difference between revisions

Revision as of 14:14, 2 May 2008

STRUCTURE OF MAMMALIAN CYTOCHROME P450 2C5

OverviewOverview

Microsomal cytochrome P450s participate in xenobiotic detoxification, procarcinogen activation, and steroid hormone synthesis. The first structure of a mammalian microsomal P450 suggests that the association of P450s with the endoplasmic reticulum involves a hydrophobic surface of the protein formed by noncontiguous portions of the polypeptide chain. This interaction places the entrance of the putative substrate access channel in or near the membrane and orients the face of the protein proximal to the heme cofactor perpendicular to the plane of the membrane for interaction with the P450 reductase. This structure offers a template for modeling other mammalian P450s and should aid drug discovery and the prediction of drug-drug interactions.

About this StructureAbout this Structure

1DT6 is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

ReferenceReference

Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity., Williams PA, Cosme J, Sridhar V, Johnson EF, McRee DE, Mol Cell. 2000 Jan;5(1):121-31. PMID:10678174 Page seeded by OCA on Fri May 2 14:14:47 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1dt6.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 1dt6 |SIZE=350|CAPTION= <scene name='initialview01'>1dt6</scene>, resolution 3.0&Aring;
+The line below this paragraph, containing "STRUCTURE_1dt6", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1dt6|  PDB=1dt6  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dt6 OCA], [http://www.ebi.ac.uk/pdbsum/1dt6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dt6 RCSB]</span>
-}}
 '''STRUCTURE OF MAMMALIAN CYTOCHROME P450 2C5'''
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 [[Category: Sridhar, V.]]
 [[Category: Williams, P A.]]
-[[Category: benzo(a)pyrene hydroxylase]]
+[[Category: Cyp2c5]]
-[[Category: cyp2c5]]
+[[Category: Estradiol 2-hydroxylase]]
-[[Category: estradiol 2-hydroxylase]]
+[[Category: Membrane protein]]
-[[Category: membrane protein]]
+[[Category: P450]]
-[[Category: p450]]
+[[Category: Progesterone 21-hydroxylase]]
-[[Category: progesterone 21-hydroxylase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:14:47 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:48:16 2008''