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==== | ==Crystal structure of the phosphatase domains of human PTP SIGMA== | ||
<StructureSection load='2fh7' size='340' side='right'caption='[[2fh7]]' scene=''> | <StructureSection load='2fh7' size='340' side='right'caption='[[2fh7]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[2fh7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FH7 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fh7 OCA], [https://pdbe.org/2fh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fh7 RCSB], [https://www.ebi.ac.uk/pdbsum/2fh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fh7 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2fh7 TOPSAN]</span></td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPRS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fh7 OCA], [https://pdbe.org/2fh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fh7 RCSB], [https://www.ebi.ac.uk/pdbsum/2fh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fh7 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2fh7 TOPSAN]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/PTPRS_HUMAN PTPRS_HUMAN]] Interacts with LAR-interacting protein LIP.1. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fh7 ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fh7 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases. | |||
Structural genomics of protein phosphatases.,Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:18058037<ref>PMID:18058037</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2fh7" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Protein-tyrosine-phosphatase]] | ||
[[Category: Almo, S C]] | |||
[[Category: Alvarado, J]] | |||
[[Category: Atwell, S]] | |||
[[Category: Bain, K T]] | |||
[[Category: Burley, S K]] | |||
[[Category: Freeman, J C]] | |||
[[Category: Kearins, M C]] | |||
[[Category: Koss, J]] | |||
[[Category: Maletic, M]] | |||
[[Category: Structural genomic]] | |||
[[Category: Ozyurt, S]] | |||
[[Category: Powell, A]] | |||
[[Category: Rooney, I]] | |||
[[Category: Russell, M]] | |||
[[Category: Sauder, J M]] | |||
[[Category: Smith, D]] | |||
[[Category: Thompson, D A]] | |||
[[Category: Udupi, R]] | |||
[[Category: Wasserman, S R]] | |||
[[Category: Dual domain phosphatase]] | |||
[[Category: Hydrolase]] | |||
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]] | |||
[[Category: PSI, Protein structure initiative]] | |||
[[Category: Receptor protein tyrosine phosphatase]] | |||
Revision as of 12:19, 24 February 2021
Crystal structure of the phosphatase domains of human PTP SIGMACrystal structure of the phosphatase domains of human PTP SIGMA
Structural highlights
Function[PTPRS_HUMAN] Interacts with LAR-interacting protein LIP.1. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases. Structural genomics of protein phosphatases.,Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:18058037[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Human
- Large Structures
- Protein-tyrosine-phosphatase
- Almo, S C
- Alvarado, J
- Atwell, S
- Bain, K T
- Burley, S K
- Freeman, J C
- Kearins, M C
- Koss, J
- Maletic, M
- Structural genomic
- Ozyurt, S
- Powell, A
- Rooney, I
- Russell, M
- Sauder, J M
- Smith, D
- Thompson, D A
- Udupi, R
- Wasserman, S R
- Dual domain phosphatase
- Hydrolase
- NYSGXRC, New York SGX Research Center for Structural Genomics
- PSI, Protein structure initiative
- Receptor protein tyrosine phosphatase