1dsm: Difference between revisions

Revision as of 14:13, 2 May 2008

(-)-duocarmycin SA covalently linked to duplex DNA

OverviewOverview

Duocarmycin SA is a member of a growing class of interesting lead compounds for chemotherapy, distinguished by the manner in which they bind to and react with DNA substrates. The first three-dimensional structure of a DNA adduct of an unnatural enantiomer from this family has been determined by (1)H NMR methods. Comparison to the previously determined structure of the natural enantiomer bound in the same DNA-binding site provides unique insights into the similarities and critical distinctions producing the respective alkylation products and site selectivities. The results also support the hypothesis that the duocarmycin SA alkylation reaction is catalyzed by the binding to DNA, and provide a deeper understanding of the structural basis for this unique mode of activation.

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

The structural basis for in situ activation of DNA alkylation by duocarmycin SA., Smith JA, Bifulco G, Case DA, Boger DL, Gomez-Paloma L, Chazin WJ, J Mol Biol. 2000 Jul 28;300(5):1195-204. PMID:10903864 Page seeded by OCA on Fri May 2 14:13:32 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1dsm.gif|left|200px]]
- {{Structure
+<!--
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+The line below this paragraph, containing "STRUCTURE_1dsm", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DSA:4-HYDROXY-8-METHYL-6-(4,5,6-TRIMETHOXY-1H-INDOLE-2-CARBONYL)-3,6,7,8-TETRAHYDRO-3,6-DIAZA-AS-INDACENE-2-CARBOXYLIC+ACID+METHYL+ESTER'>DSA</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1dsm|  PDB=1dsm  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dsm OCA], [http://www.ebi.ac.uk/pdbsum/1dsm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dsm RCSB]</span>
-}}
 '''(-)-duocarmycin SA covalently linked to duplex DNA'''
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 ==About this Structure==
-DSM is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DSM OCA].
+Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DSM OCA].
 ==Reference==
 The structural basis for in situ activation of DNA alkylation by duocarmycin SA., Smith JA, Bifulco G, Case DA, Boger DL, Gomez-Paloma L, Chazin WJ, J Mol Biol. 2000 Jul 28;300(5):1195-204. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10903864 10903864]
-[[Category: Protein complex]]
 [[Category: Case, D A.]]
 [[Category: Chazin, W J.]]
 [[Category: Smith, J A.]]
-[[Category: antitumor agent]]
+[[Category: Antitumor agent]]
-[[Category: dna]]
+[[Category: Dna]]
-[[Category: drug-dna complex]]
+[[Category: Drug-dna complex]]
-[[Category: duocarmycin]]
+[[Category: Duocarmycin]]
-[[Category: minor groove binding]]
+[[Category: Minor groove binding]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:13:32 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:47:56 2008''