1b8i: Difference between revisions

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<StructureSection load='1b8i' size='340' side='right'caption='[[1b8i]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='1b8i' size='340' side='right'caption='[[1b8i]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1b8i]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B8I FirstGlance]. <br>
<table><tr><td colspan='2'>[[1b8i]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B8I FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8i OCA], [http://pdbe.org/1b8i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b8i RCSB], [http://www.ebi.ac.uk/pdbsum/1b8i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1b8i ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8i OCA], [https://pdbe.org/1b8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b8i RCSB], [https://www.ebi.ac.uk/pdbsum/1b8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b8i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/EXD_DROME EXD_DROME]] Transcription factor which acts with the selector homeodomain proteins altering the regulation of downstream target genes such as wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting segmental identity. Delimits the eye field and prevent inappropriate eye development. Required for proper localization of chordotonal organs within the peripheral nervous system.<ref>PMID:8104703</ref> <ref>PMID:8100142</ref> <ref>PMID:7914871</ref> <ref>PMID:9346235</ref> <ref>PMID:9463350</ref> <ref>PMID:9450936</ref>  [[http://www.uniprot.org/uniprot/UBX_DROME UBX_DROME]] Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor.  
[[https://www.uniprot.org/uniprot/EXD_DROME EXD_DROME]] Transcription factor which acts with the selector homeodomain proteins altering the regulation of downstream target genes such as wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting segmental identity. Delimits the eye field and prevent inappropriate eye development. Required for proper localization of chordotonal organs within the peripheral nervous system.<ref>PMID:8104703</ref> <ref>PMID:8100142</ref> <ref>PMID:7914871</ref> <ref>PMID:9346235</ref> <ref>PMID:9463350</ref> <ref>PMID:9450936</ref>  [[https://www.uniprot.org/uniprot/UBX_DROME UBX_DROME]] Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor.  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

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