SARS-CoV-2 spike protein mutations: Difference between revisions
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Also in January, 2021, the lineage '''P.1''' was found to have increased rapidly in Manaus, Brazil<ref name="P1.1">[https://www.the-scientist.com/news-opinion/a-guide-to-emerging-sars-cov-2-variants-68387 A Guide to Emerging SARS-CoV-2 Variants] by Katarina Zimmer, ''The Scientist'', January 26, 2021.</ref><ref name="manaus1" />. P.1 has 10 mutations in the spike protein, including 3 in common with the South African lineage 501Y.V2 (N501Y, K417N, and E484K)<ref name="manaus1">[https://virological.org/t/genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-manaus-preliminary-findings/586 Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings], Nuno R. Faria ''et al.'' on behalf of the CADDE Genomic Networ,, January 12, 2021.</ref>. P.1 was found in the USA in January, 2021<ref name="P1.1" />. | Also in January, 2021, the lineage '''P.1''' was found to have increased rapidly in Manaus, Brazil<ref name="P1.1">[https://www.the-scientist.com/news-opinion/a-guide-to-emerging-sars-cov-2-variants-68387 A Guide to Emerging SARS-CoV-2 Variants] by Katarina Zimmer, ''The Scientist'', January 26, 2021.</ref><ref name="manaus1" />. P.1 has 10 mutations in the spike protein, including 3 in common with the South African lineage 501Y.V2 (N501Y, K417N, and E484K)<ref name="manaus1">[https://virological.org/t/genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-manaus-preliminary-findings/586 Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings], Nuno R. Faria ''et al.'' on behalf of the CADDE Genomic Networ,, January 12, 2021.</ref>. P.1 was found in the USA in January, 2021<ref name="P1.1" />. | ||
In February, 2021, mutations at '''position 677''' (Q677P, Q677H) were reported to have arisen independently (''convergent evolution'') in the south central and southwest USA, where they accounted for 28% (in Louisiana) and 11% (in New Mexico) of sequenced SARS-CoV-2 genomes by late January<ref name=" | In February, 2021, mutations at '''position 677''' (Q677P, Q677H) were reported to have arisen independently (''convergent evolution'') in the south central and southwest USA, where they accounted for 28% (in Louisiana) and 11% (in New Mexico) of sequenced SARS-CoV-2 genomes by late January<ref name="s677">[https://www.medrxiv.org/content/10.1101/2021.02.12.21251658v2.full-text Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677] by Emma B. Hodcroft ''et al.'', posted February 14, 2021.</ref>. | ||
===Mutations Most Concerning=== | ===Mutations Most Concerning=== | ||