CTLA-4: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. The intracellular domain is similar to that of CD28. <scene name='83/836584/Cv/2'>The complex between CTLA-4 and CD80 is formed mostly by hydrophobic contacts</scene><ref>PMID:11279502</ref>. | The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. The intracellular domain is similar to that of CD28. <scene name='83/836584/Cv/2'>The complex between CTLA-4 and CD80 is formed mostly by hydrophobic contacts</scene><ref>PMID:11279502</ref>. CTLA-4 residues are shown in ball-and-stick representation, while CD80 residues are in spacefill. | ||
==3D structures of CTLA-4== | ==3D structures of CTLA-4== | ||