Lysine-specific histone demethylase: Difference between revisions
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== Function == | == Function == | ||
'''Lysine-specific histone demethylase 1 or 1A''' (LSD1) is a flavin-dependent oxidase that catalyzes the removal of methyl groups from mono- and dimethylated lysine 4 of histone H3. LSD1 is a nuclear homolog of amine oxidase. LSD contains a SWIRM domain which is a small a-helical domain which binds DNA. It functions as histone demethylase and transcriptional corepressor. LSD1 demethylation occurs via a reaction which produces formaldehyde. LSD1 is a component of transcriptional co-repressor complex which also contains CoREST (co-repressor of element-1-silencing transcription factor)<ref>PMID:22339659</ref>.<br /> | '''Lysine-specific histone demethylase 1 or 1A''' (LSD1) is a flavin-dependent oxidase that catalyzes the removal of methyl groups from mono- and dimethylated lysine 4 of histone H3. LSD1 is a nuclear homolog of amine oxidase. LSD contains a SWIRM domain which is a small a-helical domain which binds DNA. It functions as histone demethylase and transcriptional corepressor. LSD1 demethylation occurs via a reaction which produces formaldehyde. LSD1 is a component of transcriptional co-repressor complex which also contains CoREST (co-repressor of element-1-silencing transcription factor)<ref>PMID:22339659</ref>.<br /> | ||
See also [[Lysine-specific demethylase 1 (LSD-1).<br /> | |||
'''Lysine-specific histone demethylase 2 or 1B''' (LSD2) is a flavin-dependent oxidase that catalyzes the removal of methyl groups from mono- and dimethylated lysine 9 of histone H3.<br /> | '''Lysine-specific histone demethylase 2 or 1B''' (LSD2) is a flavin-dependent oxidase that catalyzes the removal of methyl groups from mono- and dimethylated lysine 9 of histone H3.<br /> | ||
'''Lysine-specific histone demethylase 5A or KDM5A''' is essential for the repression of astrocyte differentiation<ref>PMID:29212818</ref>.<br /> | '''Lysine-specific histone demethylase 5A or KDM5A''' is essential for the repression of astrocyte differentiation<ref>PMID:29212818</ref>.<br /> | ||
'''Lysine-specific histone demethylase 5B or KDM5B or retinoblastoma-binding protein Rbbp2 homolog''' (LSD5B) is a JmjC domain containing histone demethylase and is an improtant component of DNA repair | '''Lysine-specific histone demethylase 5B or KDM5B or retinoblastoma-binding protein Rbbp2 homolog''' (LSD5B) is a JmjC domain containing histone demethylase and is an improtant component of DNA repair | ||